Differentiating malignant and benign necrotic lung lesions using kVp-switching dual-energy spectral computed tomography
| Autor: | Fajin Lv, Xiao Fan, Xing-Tao Huang, Qi Li, Tianyou Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Necrosis Dual-energy computed tomography Contrast Media Computed tomography Quantitative imaging Diagnosis Differential Lung neoplasms Medical technology Humans Medicine Radiology Nuclear Medicine and imaging R855-855.5 Lung cancer Lung Aged Aged 80 and over Inflammation medicine.diagnostic_test Receiver operating characteristic business.industry Multiparametric Analysis Research Age Factors Dual-Energy Computed Tomography Middle Aged Prognosis medicine.disease Peripheral C-Reactive Protein medicine.anatomical_structure ROC Curve Regression Analysis Female medicine.symptom Tomography X-Ray Computed business Nuclear medicine Iodine |
| Zdroj: | BMC Medical Imaging, Vol 21, Iss 1, Pp 1-9 (2021) BMC Medical Imaging |
| ISSN: | 1471-2342 |
| Popis: | Background Necrotic pulmonary lesions manifest as relatively low-density internally on contrast-enhanced computed tomography (CT). However, using CT to differentiate malignant and benign necrotic pulmonary lesions is challenging, as these lesions have similar peripheral enhancement. With the introduction of dual-energy spectral CT (DESCT), more quantitative parameters can be obtained and the ability to differentiate material compositions has been highly promoted. This study investigated the use of kVp-switching DESCT in differentiating malignant from benign necrotic lung lesions. Methods From October 2016 to February 2019, 40 patients with necrotic lung cancer (NLC) and 31 with necrotic pulmonary mass-like inflammatory lesion (NPMIL) were enrolled and underwent DESCT. The clinical characteristics of patients, CT morphological features, and DESCT quantitative parameters of lesions were compared between the two groups. Binary logistic regression analysis was performed to identify the independent prognostic factors differentiating NPMIL from NLC. Receiver operating characteristic (ROC) curves were used to assess the diagnostic performance of single-parameter and multiparametric analyses. Results Significant differences in age, C-reactive protein concentration, the slope of the spectral curve from 40 to 65 keV (K40–65 keV) of necrosis in non-contrast-enhanced scanning (NCS), arterial phase (AP) and venous phase (VP), effective atomic number of necrosis in NCS, and iodine concentration (IC) of the solid component in VP were observed between groups (all p 40–65 keV of necrosis in NCS, and IC of the solid component in VP were the most effective factors for differentiating NLC from NPMIL, with an AUC of 0.966 and percentage of correct class of 88.7%. Conclusions DESCT can differentiate malignant from benign necrotic lung lesions with a relatively high accuracy. |
| Databáze: | OpenAIRE |
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