Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamine-induced learning disability and spatial working memory in mice
| Autor: | Sung Ha Jin, Jin-Kyu Park, Noh Pal Jung, Sue Nie Park, Ki Yeul Nam |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Sapogenins Scopolamine Saponin Panax Morris water navigation task Muscarinic Antagonists Pharmacognosy complex mixtures Spatial memory Mice chemistry.chemical_compound Ginseng parasitic diseases Drug Discovery Avoidance Learning Animals Maze Learning Pharmacology chemistry.chemical_classification Protopanaxatriol Mice Inbred ICR Plants Medicinal biology Traditional medicine Learning Disabilities food and beverages Saponins musculoskeletal system biology.organism_classification Triterpenes carbohydrates (lipids) Memory Short-Term chemistry Space Perception Protopanaxadiol Araliaceae Injections Intraperitoneal Drugs Chinese Herbal |
| Zdroj: | Journal of Ethnopharmacology. 66:123-129 |
| ISSN: | 0378-8741 |
| Popis: | The effects of two ginseng saponins having a different ratio of protopanaxadiol (PD) and protopanaxatriol saponins (PT) on the learning impairment induced by scopolamine, and learning and memory in mice were investigated in a passive avoidance task and a Morris water maze task. The ratio of PD and PT was 1.24 and 1.46, respectively. Before training, the ginseng saponins were administered intraperitoneally at doses of 50 and 100 mg/kg. The two saponins improved the scopolamine-induced learning impairment at different dosages in mice, 50 and 100 mg/kg, respectively. However, the two saponins did not show a favorable effect on learning and memory in normal mice. Korean red ginseng saponin with a low PD/PT ratio had an improving effect on spatial working memory, but the saponin with a high PD/PT ratio did not. This finding suggests that the PD/PT ratio of the ginseng saponins may be an important factor in the pharmacological role of red ginseng as a medicinal herb. |
| Databáze: | OpenAIRE |
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