THE EFFECT OF SULPHAMETHOXYPYRIDAZINE ON LIVER AND PLASMA LEVELS OF VITAMIN A IN RATS
| Autor: | Mariá E. Bravo, F. Monckeberg, J. Urbina |
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| Rok vydání: | 1977 |
| Předmět: |
Male
Drug Vitamin medicine.medical_specialty media_common.quotation_subject medicine.medical_treatment Intraperitoneal injection Sulfamethoxypyridazine chemistry.chemical_compound Internal medicine medicine Animals Secretion Binding site Vitamin A Intubation Gastrointestinal media_common Pharmacology Dose-Response Relationship Drug business.industry Rats Inbred Strains Plasma levels Blood proteins Rats Endocrinology Liver chemistry Female business Injections Intraperitoneal Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 60:181-183 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1977.tb07739.x |
| Popis: | 1 Long-acting sulphonamides are highly bound to plasma proteins; the present study deals with the effects of this binding property upon a vitamin A compound also transported by plasma proteins. 2 Sulphamethoxypyridazine was administered in rats either orally or by intraperitoneal injection. 3 A significant fall in plasma vitamin A level and an increase in hepatic vitamin A concentration were observed. 4 These results suggest an interference by sulphamethoxypyridazine with the transport of vitamin A, either through competition between the drug and vitamin A for binding sites of plasma proteins, or through altered secretion of the vitamin from the liver. |
| Databáze: | OpenAIRE |
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