HLA and response to booster hepatitis B vaccination in anti-HBs-seronegative adolescents who had received primary infantile vaccination
| Autor: | Li-Yu Wang, Sheng-Kai Lin, Huei-Wen Chang Liao, Hans Hsienhong Lin |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
HBsAg Adolescent Immunization Secondary medicine.disease_cause Orthohepadnavirus HLA Antigens medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies DNA Primers Hepatitis B virus Booster (rocketry) General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Nucleic Acid Hybridization Hepatitis B biology.organism_classification medicine.disease Vaccination Infectious Diseases Hepadnaviridae Case-Control Studies Cohort Immunology Molecular Medicine Female business |
| Zdroj: | Vaccine. 26:3414-3420 |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2008.04.038 |
| Popis: | To explore contemporarily genetic and non-genetic determinants of long-term immunological memory to hepatitis B (HB) vaccination, we conducted a case-control study nested in an adolescent cohort of booster recipients who had received primary infantile HB vaccination but with residual anti-HBs titers10 mIU/mL at 15-18 years of age. High-resolution phenotypes of human leukocyte antigen (HLA)-A, -B, and -DRB1 loci were determined by sequence-specific oligonucleotide probe hybridization. After controlling for pre-booster anti-HBs levels, the absences of HLA-A*02 and -DRB1*08, simply expressed as A*02(-) and -DRB1*08(-), and the presence of B*15 were significantly associated with elevated risks of non-response (post-booster anti-HBs titers10 mIU/mL) to booster vaccination. The adjusted odds ratios (ORs) were 3.85 (CI, 1.82-8.33), 4.55 (CI, 1.23-16.67), 3.59 (CI, 1.40-9.17), respectively. There was multiplicative synergism between A*02 and B*15 on the risk of non-response to booster vaccination. The multivariate-adjusted ORs for A*02(-)/B*15, A*02(-)/B*15(-), A*02/B*15, and A*02/B*15(-) haplotypes were 20.39 (p=0.0003), 3.29 (p=0.007), 1.32 (p0.05), and 1.0, respectively. Recent cigarette smoking and/or betel-quid chewing was associated with a 12-fold risk of non-response to booster vaccination. Further comparisons between responders and adolescents who had undetectable post-booster anti-HBs titers (0.1 mIU/mL) demonstrated similar results. Our results indicated that response to booster HB vaccination as well as long-term immunological responses to HB vaccination are closely related with host genetic factors, and probably modified by recent substance use. |
| Databáze: | OpenAIRE |
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