| Autor: |
Dieter Neumeier, Patrick A. Baeuerle, Sharon Page, AK Walli, Korbinian Brand |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Experimental Physiology. 82:297-304 |
| ISSN: |
0958-0670 |
| DOI: |
10.1113/expphysiol.1997.sp004025 |
| Popis: |
Transcription factors of the nuclear factor-kappa B (NF-kappa B)/Rel family have an important function in the regulation of a variety of genes involved in the inflammatory and proliferative responses of cells. Recent studies strongly indicate that the inducible transcription factor NF-kappa B is involved in the pathogenesis of atherosclerosis. Activated NF-kappa B is present in the fibrotic thickened intima-media and atheromatous areas of the atherosclerotic lesion, within smooth muscle cells, macrophages and endothelial cells, whereas little or no activated NF-kappa B can be detected in vessels lacking atherosclerosis. A variety of molecules have been identified in the atherosclerotic environment that are able to activate NF-kappa B in vitro. Furthermore, an increased expression of numerous genes known to be regulated by NF-kappa B has been found in the atherosclerotic lesion. Possible functional implications for activated NF-kappa B in atherogenesis are discussed here. The activation and role of NF-kappa B in atherosclerosis may provide a model for the involvement of the transcription factor in human chronic inflammatory disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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