Keratin 17-positive Civatte bodies in oral lichen planus-distribution variety, diagnostic significance and histopathogenesis
| Autor: | Takashi Saku, Tetsuichiro Inai, Satoshi Maruyama, Shohei Yoshimoto, Norio Kitagawa, Tatsuya Abé, Manabu Yamazaki, Shuichi Hashimoto |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Oral anatomy Civatte bodies lcsh:Medicine Diseases Keratin 17 Article Lymphocytic Infiltrate 03 medical and health sciences 0302 clinical medicine stomatognathic system Oral and maxillofacial pathology Biopsy Medicine Humans Colloids lcsh:Science Skin Inflammation Lamina propria Multidisciplinary Keratin-17 medicine.diagnostic_test integumentary system business.industry lcsh:R Mouth Mucosa medicine.disease Dyskeratosis stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Case-Control Studies Oral lichen planus lcsh:Q business 030217 neurology & neurosurgery Lichen Planus Oral |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) |
| ISSN: | 2045-2322 |
| Popis: | Although emergence of keratin 17 (K17) and reciprocal loss of K13 are immunohistochemical hallmarks for oral mucosal malignancy, we report here findings of K17-positive (+) speckles, possibly equivalent to Civatte bodies, in benign oral lichen planus. Sixty-two biopsy samples from oral lichen planus cases were subjected to immunohistochemical examinations to analyze the distribution as well as histopathogenesis of Civatte bodies. K17 was irregularly positive among oral lichen planus-affected epithelial cells, and K17-positive (+) filamentous structures were irregularly distributed within the cytoplasm in confocal images. K17+ speckles were identified as Civatte bodies, and they were mainly distributed in the interface between epithelial cells and lymphocytic infiltrates (type A, 52.8%), followed by distribution within the epithelial layer (type B, 24.7%) or within the lamina propria with lymphocytic infiltration (type C, 22.5%). Apoptotic figures were often engulfed by macrophages and clearly distinguished from Civatte bodies by the presence TUNEL signals. These results indicate that K17 is a sensitive immunohistochemical marker for Civatte bodies and useful for differential diagnosis of oral lichen planus from other oral mucosal lesions. Civatte bodies are generated from denucleation of K17+ epithelial cells during the process of cell death via dyskeratosis, which is possibly related to blood capillary collapse. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|