Analysis of Allogeneic and Syngeneic Rat Heart Transplants Using23Na Magnetic Resonance Spectroscopy
| Autor: | Diane Z. Alexander, Ioannis Constantinidis, Kevin J. Winn, Thomas C. Pearson, R P Lowry, Sandra M. Waldrop |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Time Factors Biophysics Biochemistry In vivo Animals Transplantation Homologous Medicine Rats Wistar Molecular Biology business.industry Sodium Organ Size Cell Biology Rat heart Rats Rats Inbred ACI Sharp rise Transplantation Isogeneic surgical procedures operative Rats Inbred Lew Allograft rejection Immunology Heart Transplantation business |
| Zdroj: | Biochemical and Biophysical Research Communications. 223:379-383 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1996.0902 |
| Popis: | This study defines the total sodium-23 magnetic resonance spectroscopy ( 23 Na MRS) signal from in vivo heterotopic rat heart transplants in the early post-transplant period and examines the utility of this noninvasive method for monitoring allograft rejection. Measurements were performed at 4.7 T. Syngeneic (n = 6) and allogeneic (n = 6) donor hearts were transplanted into the neck of recipient rats. There were 27 MRS observations between days 0 and 29 post-transplant. Heart grafts were excised at various intervals post-transplant for histologic examination. Allogeneic heart grafts rejected between days 4 and 5 post-transplant while syngeneic grafts continued to beat. All hearts showed ischemic damage. Allogeneic hearts showed cellular rejection by Day 1. 23 Na MRS showed a steady elevation in signal in the 3 days prior to rejection and a sharp rise after rejection. 23 Na MRS accurately identified full rejection and was also sensitive to the rejection process. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect