Atrial natriuretic peptide in multiple system atrophy
| Autor: | Enrica Chebat, Angela Rogolino, Simona Piazza, Maurizio Bevilacqua, Raffaello Furlan, Velella Righini, Lucia Castelli, G. Norbiato, Tarcisio Vago |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Vasopressin Baroreceptor Vasopressins Physiology Posture Diuresis Hemodynamics Blood Pressure Blood volume Sodium Chloride Atrial natriuretic peptide Physiology (medical) Internal medicine Humans Medicine Saline Solution Hypertonic Brain Diseases Blood Volume business.industry Osmolar Concentration Middle Aged Plasma osmolality Endocrinology Blood pressure Hypertension Nerve Degeneration cardiovascular system Female Isotonic Solutions business Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.1996.271.4.r1047 |
| Popis: | Central nervous system feedback loops centered on hypothalamic neurons control atrial natriuretic peptide (ANP). We evaluated the ANP response to arterial hypotension, isotonic blood volume expansion, and increase in plasma osmolality in 14 patients with multiple system atrophy (MSA). Seven of the patients were characterized by a lack of vasopressin response to hypotension (MSA type B), suggesting chronic sinoaortic denervation, and seven by a preserved response (MSA type A). Orthostatic hypotension decreased ANP in controls and type A patients, whereas ANP in type B was not affected. Isotonic saline infusion increased ANP and diuresis in controls and type A patients, whereas it did not affect ANP in type B. Osmotic load increased plasma osmolality and vasopressin in controls and MSA patients and ANP in controls and type A but not in type B patients. In MSA patients with altered afferent control of vasopressin, ANP secretion is not stimulated by blood volume expansion, osmotic load, or blood pressure, suggesting that afferent excitatory control plays a role in the release of ANP. |
| Databáze: | OpenAIRE |
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