Association of Plasminogen Activator Inhibitor-1 Gene Polymorphisms and Methylene Tetrahydrofolate Reductase Polymorphisms with Spontaneous Miscarriages
| Autor: | Silva Zupančić-Šalek, Iva Buterin, Petra Bubalo, Zrinko Šalek, Vesna Ðogić |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Heterozygote Genotype 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Pregnancy Internal medicine Statistical significance Plasminogen Activator Inhibitor 1 medicine Odds Ratio Humans Statistical analysis Genetic Predisposition to Disease Gene Methylenetetrahydrofolate Reductase (NADPH2) Polymorphism Genetic biology business.industry Significant difference Gene polymorphisms · Methylene tetrahydrofolate Hematology General Medicine medicine.disease 030210 environmental & occupational health Abortion Spontaneous Endocrinology chemistry Methylenetetrahydrofolate reductase Plasminogen activator inhibitor-1 Case-Control Studies biology.protein Female business Plasminogen activator |
| Zdroj: | Acta haematologica. 138(2) |
| ISSN: | 1421-9662 |
| Popis: | Aim: The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM). Materials and Methods: PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history compared to 46 women in the control group. For statistical analysis, χ2 test, Phi, and Cramer V tests were used; p < 0.05 was taken as a statistically significant result. Results: Our findings show: (a) the correlation between SM and PAI-1 mutations reaches statistical significance (p = 0.026); (b) there was a statistically significant difference between heterozygous PAI-1 in women with only 1 SM compared to the control group (p = 0.047); (c) the comparison of combinations of both mutations, PAI-1 and MTHFR, with the control group demonstrates statistical significance in favor of women with SM and both mutations (p = 0.022). Conclusion: PAI-1 and MTHFR polymorphisms may play an important role in pregnancy complications because heterozygous PAI-1 mutations and a combination of both PAI-1 and MTHFR mutations might contribute to SM. |
| Databáze: | OpenAIRE |
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