Distinct Regions of the Striatum Underlying Effort, Movement Initiation, and Effort Discounting
| Autor: | Amanda R. Arulpragasam, Victoria M. Lawlor, Jessica A. Cooper, Michael T. Treadway, Shosuke Suzuki |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
effort discounting
Adult Social Psychology Decision Making Experimental and Cognitive Psychology Context (language use) Striatum Motor Activity Brain mapping naturalistic stimuli Article 03 medical and health sciences Behavioral Neuroscience Young Adult 0302 clinical medicine value-based decision-making Reward medicine Humans 030304 developmental biology 0303 health sciences Discounting Brain Mapping Motivation medicine.diagnostic_test Movement (music) Ventral striatum fMRI Magnetic Resonance Imaging medicine.anatomical_structure Action (philosophy) Ventral Striatum Psychology Functional magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery Psychomotor Performance Spatial Navigation |
| Zdroj: | Nature human behaviour |
| ISSN: | 2397-3374 |
| Popis: | The ventral striatum is believed to encode the subjective value of cost-benefit options; however, this effect has notably been absent during choices that involve physical effort. Previous work in freely moving animals has revealed opposing striatal signals, with greater response to increasing effort demands and reduced responses to rewards requiring effort. Yet, the relationship between these conflicting signals remains unknown. Using functional magnetic resonance imaging with a naturalistic maze-navigation paradigm, we identified functionally segregated regions within the ventral striatum that separately encoded effort activation, movement initiation and effort discounting of rewards. In addition, activity in regions associated with effort activation and discounting oppositely predicted striatal encoding of effort during effort-based decision-making. Our results suggest that the dorsomedial region hitherto associated with action may instead represent the cost of effort and raise fundamental questions regarding the interpretation of striatal 'reward' signals in the context of effort demands. This has implications for uncovering the neural architecture underlying motivated behaviour. |
| Databáze: | OpenAIRE |
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