Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study
Autor: | Ayse Sahin-Efe, Kyung Hee Park, Jagriti Upadhyay, Fadime Dincer, Christos S. Mantzoros, Byung Joon Ko, Alexandra L. Migdal, Pantel S. Vokonas |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Leptin Male medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Diabetes mellitus Internal medicine medicine Humans Longitudinal Studies Obesity Prospective Studies Aged Glucose tolerance test medicine.diagnostic_test business.industry Case-control study Glucose Tolerance Test Middle Aged medicine.disease Impaired fasting glucose Fibronectins 030104 developmental biology Cross-Sectional Studies Diabetes Mellitus Type 2 Case-Control Studies Female business |
Zdroj: | Metabolism: clinical and experimental. 79 |
ISSN: | 1532-8600 |
Popis: | To investigate the associations between irisin and leptin levels in obesity and insulin resistance in a cross sectional study. To assess the potential role of irisin and leptin as a predictive marker of T2DM using a nested case-control study.Both studies were designed within the longitudinal VA NAS cohort. The cross sectional study involved 111 non obese and 105 obese subjects who were subdivided into two groups based on their fasting glucose tolerance. In the nested 1:3 case-control study, 47 subjects with T2DM and 140 non-diabetic controls were selected. Serum samples collected 3-5 years before the diagnosis of T2DM were analyzed. Irisin and leptin concentrations were measured using a validated ELISA and radioimmunoassay respectively.In the cross-sectional study, irisin did not differ between groups based on their fasting glucose tolerance. When subjects were grouped based on obesity status, both irisin and leptin concentrations were significantly higher in obese compared to the non-obese group (p=0.03 and0.001, respectively). Irisin concentrations positively correlated with leptin concentrations (r= 0.392, P0.001). In the nested case control study, leptin concentrations were a significant predictor of developing diabetes (p=0.005) in unadjusted models, but not after correcting for BMI, whereas irisin concentrations did not play a role of comparable significance.Leptin concentrations are higher in the obese group irrespective of their glucose tolerance. Obese individuals with impaired fasting glucose have higher concentrations of circulating irisin compared to non-obese subjects with normal glucose tolerance. Irisin concentrations do not predict risk of developing diabetes prospectively. |
Databáze: | OpenAIRE |
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