Synergistic effects of dopamine D2-like receptor antagonist sulpiride and beta-blocker propranolol on learning in the Carousel maze, a dry-land spatial navigation task
| Autor: | Tomas Petrasek, Vanessa M. Doulames, Karel Vales, Iva Prokopova, Ales Stuchlik, Jan Svoboda, Stepan Bahnik |
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| Rok vydání: | 2012 |
| Předmět: |
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medicine.drug_class Adrenergic beta-Antagonists Clinical Biochemistry Spatial Behavior Hippocampus Propranolol Pharmacology Toxicology Biochemistry Spatial memory Task (project management) Behavioral Neuroscience Dopamine Dopamine receptor D2 medicine Animals Rats Long-Evans Maze Learning Biological Psychiatry Receptors Dopamine D2 Drug Synergism Receptor antagonist Rats Dopamine D2 Receptor Antagonists Dopamine Antagonists Sulpiride Psychology Neuroscience Psychomotor Performance psychological phenomena and processes medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 102:151-156 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2012.04.003 |
| Popis: | Spatial navigation attracts the attention of neuroscientists as an animal analogue of human declarative memory. The Carousel maze is a dry-land navigational paradigm, which proved to be useful in studying neurobiological substrates of learning. The task involves avoidance of a stable sector on a rotating arena and is highly dependent upon the hippocampus. The present study aims at testing hypothesis that sulpiride (a centrally-active dopamine D2-like receptor antagonist) and propranolol (a beta-blocker) impair spatial learning in the Carousel maze after combined systemic administration. These doses were previously shown to be subthreshold in this task. Results showed that both substances affected behavior and significantly potentiated their negative effects on spatial learning. This suggests central interaction of both types of receptors in influencing acquisition of this dynamic-environment task. |
| Databáze: | OpenAIRE |
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