Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG
Autor: | Markus Gschwind, Ulrich Roelcke, Margherita Carboni, Margitta Seeck, Silke Biethahn, Janina Tepperberg, Ana Coito, Pieter van Mierlo, Serge Vulliemoz |
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Rok vydání: | 2018 |
Předmět: |
inorganic chemicals
focal epilepsy Concordance 0206 medical engineering 02 engineering and technology Electroencephalography lcsh:RC346-429 Temporal lobe 03 medical and health sciences Epilepsy 0302 clinical medicine Directed functional connectivity Electrical source imaging medicine Ictal Epileptogenic zone Source imaging low‐density EEG lcsh:Neurology. Diseases of the nervous system medicine.diagnostic_test business.industry organic chemicals technology industry and agriculture Focal epilepsy medicine.disease 020601 biomedical engineering ddc:616.8 Neurology Brain size Full‐length Original Research lipids (amino acids peptides and proteins) Neurology (clinical) Low-density EEG directed functional connectivity Nuclear medicine business electrical source imaging epileptogenic zone 030217 neurology & neurosurgery |
Zdroj: | Epilepsia Open Epilepsia Open, Vol. 4, No 2 (2019) pp. 281-292 Epilepsia Open, Vol 4, Iss 2, Pp 281-292 (2019) |
ISSN: | 2470-9239 |
Popis: | Summary Objective Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high‐density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low‐density clinical electroencephalography (EEG). Methods We selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standard EEG, (c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20 temporal lobe epilepsy [TLE], 14 extra‐TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient‐specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger‐causal modeling followed by network topologic measures. The concordance with the presumed EZ at the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure‐free patients. Results ESI, summed outflow, and efficiency were concordant with the presumed EZ in 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference between ESI and connectivity measures. In all measures, patients with TLE had a significantly higher (P |
Databáze: | OpenAIRE |
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