Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low-density EEG

Autor: Markus Gschwind, Ulrich Roelcke, Margherita Carboni, Margitta Seeck, Silke Biethahn, Janina Tepperberg, Ana Coito, Pieter van Mierlo, Serge Vulliemoz
Rok vydání: 2018
Předmět:
inorganic chemicals
focal epilepsy
Concordance
0206 medical engineering
02 engineering and technology
Electroencephalography
lcsh:RC346-429
Temporal lobe
03 medical and health sciences
Epilepsy
0302 clinical medicine
Directed functional connectivity
Electrical source imaging
medicine
Ictal
Epileptogenic zone
Source imaging
low‐density EEG
lcsh:Neurology. Diseases of the nervous system
medicine.diagnostic_test
business.industry
organic chemicals
technology
industry
and agriculture
Focal epilepsy
medicine.disease
020601 biomedical engineering
ddc:616.8
Neurology
Brain size
Full‐length Original Research
lipids (amino acids
peptides
and proteins)
Neurology (clinical)
Low-density EEG
directed functional connectivity
Nuclear medicine
business
electrical source imaging
epileptogenic zone
030217 neurology & neurosurgery
Zdroj: Epilepsia Open
Epilepsia Open, Vol. 4, No 2 (2019) pp. 281-292
Epilepsia Open, Vol 4, Iss 2, Pp 281-292 (2019)
ISSN: 2470-9239
Popis: Summary Objective Electrical source imaging (ESI) is used increasingly to estimate the epileptogenic zone (EZ) in patients with epilepsy. Directed functional connectivity (DFC) coupled to ESI helps to better characterize epileptic networks, but studies on interictal activity have relied on high‐density recordings. We investigated the accuracy of ESI and DFC for localizing the EZ, based on low‐density clinical electroencephalography (EEG). Methods We selected patients with the following: (a) focal epilepsy, (b) interictal spikes on standard EEG, (c) either a focal structural lesion concordant with the electroclinical semiology or good postoperative outcome. In 34 patients (20 temporal lobe epilepsy [TLE], 14 extra‐TLE [ETLE]), we marked interictal spikes and estimated the cortical activity during each spike in 82 cortical regions using a patient‐specific head model and distributed linear inverse solution. DFC between brain regions was computed using Granger‐causal modeling followed by network topologic measures. The concordance with the presumed EZ at the sublobar level was computed using the epileptogenic lesion or the resected area in postoperative seizure‐free patients. Results ESI, summed outflow, and efficiency were concordant with the presumed EZ in 76% of the patients, whereas the clustering coefficient and betweenness centrality were concordant in 70% of patients. There was no significant difference between ESI and connectivity measures. In all measures, patients with TLE had a significantly higher (P
Databáze: OpenAIRE
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