Prevalence of Autism Spectrum Disorders with and without Intellectual Disability by Gestational Age at Birth in the Stockholm Youth Cohort: a Register Linkage Study

Autor: Dheeraj Rai, Craig J. Newschaffer, Christina Dalman, Hein Heuvelman, Kristen Lyall, Kathryn M. Abel, Brian K. Lee, Cecilia Magnusson, Sherlly Xie
Rok vydání: 2017
Předmět:
Male
Pediatrics
genetic structures
Autism Spectrum Disorder
Epidemiology
Comorbidity
postterm
0302 clinical medicine
Pregnancy
Risk Factors
Fetal sex
Intellectual disability
Prevalence
030212 general & internal medicine
Child
gestational age
Gestational age
intellectual disability
Cohort
Gestation
Female
generalised additive model
Infant
Premature
Cohort study
medicine.medical_specialty
Adolescent
autism spectrum disorders
Gestational Age
Risk Assessment
behavioral disciplines and activities
Infant
Postmature
03 medical and health sciences
Sex Factors
Intellectual Disability
mental disorders
Journal Article
medicine
Humans
Pediatrics
Perinatology
and Child Health
Sweden
business.industry
Infant
Newborn
medicine.disease
Relative risk
Pediatrics
Perinatology and Child Health
Autism
preterm
business
030217 neurology & neurosurgery
Zdroj: Xie, S, Heuvelman, H, Magnusson, C, Rai, D, Lyall, K, Newschaffer, C J, Dalman, C, Lee, B K & Abel, K 2017, ' Prevalence of Autism Spectrum Disorders with and without Intellectual Disability by Gestational Age at Birth in the Stockholm Youth Cohort : a Register Linkage Study ', Paediatric and perinatal epidemiology, vol. 31, no. 6, pp. 586-594 . https://doi.org/10.1111/ppe.12413
Xie, S, Heuvelman, H, Magnusson, C, Rai, D, Lyall, K, Newschaffer, C J, Dalman, C, Lee, B K & Abel, K 2017, ' Prevalence of Autism Spectrum Disorders with and without Intellectual Disability by Gestational Age at Birth in the Stockholm Youth Cohort : a Register Linkage Study ', Paediatric and Perinatal Epidemiology, vol. 31, no. 6, pp. 586-594 . https://doi.org/10.1111/ppe.12413
ISSN: 0269-5022
1984-2007
Popis: BACKGROUND: Preterm birth has been linked to increased risk of autism spectrum disorders (ASD), but how this risk changes with gestational age at birth has not been well characterised, especially with regard to co-occurring intellectual disability (ID).METHODS: Register-based cohort study of singleton births in 1984-2007 in Stockholm County, Sweden (N total: 480 728; n ASD: 10 025). We assessed overall and sex-specific, gestational week-specific prevalence estimates and risk ratios of ASD with and without ID.RESULTS: Preterm and postterm births were associated with elevated risk of ASD, and the relationship between gestational age at birth and ASD with and without ID differed in males and females. Risk of ASD without ID was higher in preterm births among both sexes and decreased continuously with increasing length of gestation. Risk of ASD with ID was higher in both preterm and postterm births among both sexes, with postterm birth in females being more highly associated with ASD with ID than that in males.CONCLUSIONS: The relationship between gestational age at birth and ASD differs by the presence/absence of co-occurring ID and fetal sex. Both preterm and postterm birth are associated with increased risk of ASD. Risk of ASD is not constant within conventionally defined gestational age at birth periods. Further research on mechanism underlying these associations is needed.
Databáze: OpenAIRE
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