Wistar rats: a forgotten model of age-related hearing loss
| Autor: | Juan Carlos Alvarado, José Luis Blanco, Verónica Fuentes-Santamaría, José M. Juiz, María C. Gabaldón-Ull |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Senescence
Aging medicine.medical_specialty Hearing loss Cognitive Neuroscience Vesicular glutamate transporter 1 Sensory system Inhibitory postsynaptic potential cochlear nucleus Cochlear nucleus lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Original Research Article lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry 030304 developmental biology hearing loss 0303 health sciences biology business.industry rat model auditory brainstem response (ABR) Endocrinology presbyacusis biology.protein Excitatory postsynaptic potential Brainstem vesicular transport proteins medicine.symptom business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 6 (2014) Frontiers in Aging Neuroscience; Vol 6 |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2014.00029 |
| Popis: | Age-related hearing loss (ARHL) is one of the most frequent sensory impairments in senescence and is a source of important socio-economic consequences. Understanding the pathological responses that occur in the central auditory pathway of patients who suffer from this disability is vital to improve its diagnosis and treatment. Therefore, the goal of this study was to characterize age-related modifications in auditory brainstem responses (ABR) and to determine whether these functional responses might be accompanied by an imbalance between excitation and inhibition in the cochlear nucleus of Wistar rats. To do so, ABR recordings at different frequencies and immunohistochemistry for the vesicular glutamate transporter 1 (VGLUT1) and the vesicular GABA transporter (VGAT) in the ventral cochlear nucleus (VCN) were performed in young, middle-aged and old male Wistar rats. The results demonstrate that there was a significant increase in the auditory thresholds, a significant decrease in the amplitudes and an increase in the latencies of the ABR waves as the age of the rat increased. Additionally, there were decreases in VGLUT1 and VGAT immunostaining in the VCN of older rats compared to younger rats. Therefore, the observed age-related decline in the magnitude of auditory evoked responses might be due in part to a reduction in markers of excitatory function; meanwhile, the concomitant reduction in both excitatory and inhibitory markers might reflect a common central alteration in animal models of ARLH. Together, these findings highlight the suitability of the Wistar rat as an excellent model to study ARHL. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|