Heavy metals controlling cardiovascular diseases risk factors in myocardial infarction patients in critically environmentally heavy metal-polluted steel industrial town Mandi-Gobindgarh (India)
| Autor: | Reshu Mandal, Vinod Kumar Gupta, Sukhbir Kaur, Amit Joshi |
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| Rok vydání: | 2021 |
| Předmět: |
China
medicine.medical_specialty Environmental Engineering Myocardial Infarction Overweight Risk Assessment Gastroenterology Electrolytes chemistry.chemical_compound Risk Factors Geochemistry and Petrology Metals Heavy Internal medicine medicine Humans Environmental Chemistry Myocardial infarction Aldosterone Triglycerides General Environmental Science Water Science and Technology biology business.industry Cholesterol Cholesterol HDL C-reactive protein General Medicine Environmental exposure medicine.disease C-Reactive Protein Lead chemistry 8-Hydroxy-2'-Deoxyguanosine Cardiovascular Diseases Steel biology.protein Hypernatremia medicine.symptom business Body mass index Environmental Monitoring |
| Zdroj: | Environmental Geochemistry and Health. 44:3215-3238 |
| ISSN: | 1573-2983 0269-4042 |
| Popis: | Heavy metals (HMs) have a very significant clinical role in the pathogenesis, progression and management of cardiovascular diseases (CVDs). The prevalence of CVDs was reported to be higher in critically environmentally HM-polluted (EHMP) steel industrial town Mandi-Gobindgarh (India) for the last more than a decade. To ascertain the role of HMs in the onset of CVDs, the present study was chosen to investigate HMs content in myocardial infarction (MI) patients from EHMP steel industrial town Mandi-Gobindgarh. Total of 110 MI patients along with number- and age-matched healthy volunteers were recruited in the present investigation. The CVDs risk factors estimated in MI patients were overweight (higher body mass index), hypertension (higher systolic and diastolic blood pressures), dyslipidaemia (higher serum cholesterol, triglycerides and lower HDL cholesterol), inflammation (higher-serum C reactive protein and aldosterone) and elevated oxidative stress (higher urinary 8-hydroxydeoxyguanosine). An imbalance of serum electrolyte concentrations including Na (hypernatremia), Ca (hypercalcaemia) and K (hypokalaemia) was also observed in MI patients in which CVDs risk factors were found to correlate positively with serum Na and Ca and negatively with serum K, respectively. Hair HM analysis was used as a bio-indicator for monitoring body HM status from past environmental HM exposure in which CVDs risk factors were observed to correlate positively with higher hair concentrations of Zn, Fe, Mo, Pb, As, Ca and Na and negatively with lower hair concentrations of Cu, Mg, Mn and K in MI patients, respectively. Thus, higher hair concentrations of Zn and Pb indicate their higher environmental exposure and possible cause of higher CVDs risk factors in MI patients from Mandi-Gobindgarh. |
| Databáze: | OpenAIRE |
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