The d4 gene family in the human genome
| Autor: | Maria V. Kost, Georgy P. Georgiev, Alexander V. Chestkov, Ivan D. Baka, Vladimir L. Buchman |
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| Rok vydání: | 1996 |
| Předmět: |
RNA Splicing
Molecular Sequence Data Nerve Tissue Proteins Biology Genome Conserved sequence Gene density Chromosome 19 Sequence Homology Nucleic Acid Gene cluster Genetics Gene family Animals Humans Amino Acid Sequence Gene Conserved Sequence Base Sequence Sequence Homology Amino Acid Genome Human Chromosome Mapping Zinc Fingers Exons Rats Multigene Family Human genome Chromosomes Human Pair 19 Transcription Factors |
| Zdroj: | Genomics. 36(1) |
| ISSN: | 0888-7543 |
| Popis: | The d4 domain, a novel zinc finger-like structural motif, was first revealed in the rat neuro-d4 protein. Here we demonstrate that the d4 domain is conserved in evolution and that three related genes form a d4 family in the human genome. The human neuro-d4 is very similar to rat neuro-d4 at both the amino acid and the nucleotide levels. Moreover, the same splice variants have been detected among rat and human neuro-d4 transcripts. This gene has been localized on chromosome 19, and two other genes, members of the d4 family isolated by screening of the human genomic library at low stringency, have been mapped to chromosomes 11 and 14. The gene on chromosome 11 is the homolog of the ubiquitously expressed mouse gene ubi-d4/requiem, which is required for cell death after deprivation of trophic factors. A gene with a conserved d4 domain has been found in the genome of the nematodeCaenorhabditis elegans.The conservation of d4 proteins from nematodes to vertebrates suggests that they have a general importance, but a diversity of d4 proteins expressed in vertebrate nervous systems suggests that some family members have special functions. |
| Databáze: | OpenAIRE |
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