OCCURRENCE OF AUTOANTIBODIES TO HUMAN-LEUKOCYTE ELASTASE IN WEGENERS GRANULOMATOSIS AND OTHER INFLAMMATORY DISORDERS
| Autor: | J W Tervaert, L Mulder, C Stegeman, J Elema, M Huitema, H The, C Kallenberg |
|---|---|
| Přispěvatelé: | Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR) |
| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Male
Systemic disease Pathology Myeloid SYSTEMIC LUPUS-ERYTHEMATOSUS DISEASE Glomerulonephritis CYTOPLASMIC AUTOANTIBODIES Immunology and Allergy VASCULITIS MYELOID LYSOSOMAL-ENZYMES Aged 80 and over Pancreatic Elastase biology Serine Endopeptidases Elastase MYELOPEROXIDASE Middle Aged ANTI-ELASTASE medicine.anatomical_structure Myeloperoxidase Female Vasculitis CRESCENTIC GLOMERULONEPHRITIS Research Article Systemic vasculitis medicine.medical_specialty Myeloblastin Immunology Enzyme-Linked Immunosorbent Assay General Biochemistry Genetics and Molecular Biology Antibodies Antineutrophil Cytoplasmic Rheumatology medicine Humans Aged Autoantibodies Peroxidase Anti-neutrophil cytoplasmic antibody business.industry Granulomatosis with Polyangiitis Autoantibody medicine.disease Immunoglobulin G ANTIBODIES biology.protein sense organs HUMAN-NEUTROPHILS Leukocyte Elastase business |
| Zdroj: | Annals of the Rheumatic Diseases, 52(2), 115-120. BMJ PUBLISHING GROUP |
| ISSN: | 0003-4967 |
| Popis: | Antineutrophil cytoplasmic antibodies (ANCAs) constitute a new class of autoantibodies that seem to recognise myeloid lysosomal enzymes. The occurrence of ANCAs with specificity for human leucocyte elastase (HLE) was assessed in serum samples that were routinely submitted for ANCA determination. During a study period of more than six years anti-HLE was found in only six out of 1102 serum samples that produced a perinuclear or an atypical cytoplasmic staining pattern on ethanol fixed granulocytes. These six serum samples were from four patients with a clinical diagnosis of Wegener's granulomatosis but without a definite histological diagnosis, one patient with systemic vasculitis, and one patient with Cogan's syndrome. To further evaluate the prevalence of anti-HLE we tested 315 serum samples from patients with different forms of vasculitis and related disorders. Anti-HLE was detected in two patients only. Thus autoantibodies to HLE are rarely found in serum samples from patients with vasculitic or related disorders. |
| Databáze: | OpenAIRE |
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