The Evaluation of Vitamin K Status in Children with Febrile Seizure
Autor: | Kürşat Bora, Carman, Yasemin, Karal, Gül, Gülen Mert, Arzu, Ekici, Peren, Perk, Coşkun, Yarar, Çağatay, Nuhoğlu, Gürkan, Bozan, Ömer, Kılıç, Meltem, Dinleyici, Sabiha, Şahin, Emrah, Atay, Uğur, Tokdemir, Baver, Demir, Ener Çağrı, Dinleyici, Dinleyici Ec Efes, Study Group |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male Vitamin medicine.medical_specialty Vitamin K Adolescent Interleukin-1beta Neurological disorder Vitamin k Gastroenterology Seizures Febrile Statistics Nonparametric chemistry.chemical_compound Febrile seizure Internal medicine medicine Humans Prospective Studies Child Interleukin 6 biology Interleukin-6 business.industry Vitamin K2 [No Keywords] General Medicine Middle Aged medicine.disease Pathophysiology Logistic Models chemistry Case-Control Studies Child Preschool biology.protein Medicine Female Vitamin K Deficiency Tumor necrosis factor alpha business |
Zdroj: | Balkan Medical Journal, Vol 38, Iss 2, Pp 116-120 (2021) |
ISSN: | 2146-3131 2146-3123 |
Popis: | Background: Febrile seizure is the most common neurological disorder in childhood. The exact pathophysiology of febrile seizures is unknown. Recent studies showed the role of vitamin K in nonhematological and inflammatory disorders. This study aimed to investigate the serum vitamin K levels in children with febrile seizures. Aims: To evaluate vitamin K levels in children with febrile seizures. Study Design: Prospective case-control study. Methods: This multicenter study examined representative populations in 8 different cities in Turkey between April 1, 2018 and April 1, 2019. Blood samples were taken from all children at presentation. Vitamin K1, vitamin K2, tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels were determined by enzyme-linked immunosorbent assay. Results: A total of 155 children were included in the study—84 children with febrile seizures and 71 children in febrile control group. Serum vitamin K1 and vitamin K2 levels were also higher in children with febrile seizures than in the controls. The results of statistical analysis showed that vitamin K1 and vitamin K2 levels were correlated with tumor necrosis factor-alpha, interleukin 1 beta, and interleukin 6 levels. The median vitamin K1 and vitamin K2 levels of children experiencing their first febrile seizure were higher than those in children with recurrent febrile seizures. Type of febrile seizure has no effect on serum vitamin K1 and vitamin K2 levels. Conclusion: In children with febrile seizures, vitamin K levels are higher than those in the control group. These new findings may contribute to elucidating the etiopathogenesis of febrile seizures. |
Databáze: | OpenAIRE |
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