Progress in implantable gastric stimulation: summary of the results of the European multi-center study
| Autor: | Jorge Limão, Matthias Scheyer, Heinrich Penthaler, Luca Busetto, Franz Aigner, Charles de Gheldere, Franco Favretti, Giorgio Gaggiotti, Jacques Himpens, Ernst L. Zurmeyer, Mauro Toppino, Maurizio De Luca, Helmut Weiss, Gianni Segato, Giorgio Bottani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Peptide Hormones Appetite Stimulation Electric Stimulation Therapy Satiety Response Stomach surgery Weight loss Weight Loss medicine Humans Prospective Studies Laparoscopy Prospective cohort study Aged Nutrition and Dietetics medicine.diagnostic_test business.industry Stomach Middle Aged Ghrelin Surgery Electrodes Implanted Obesity Morbid Clinical trial Europe medicine.anatomical_structure Treatment Outcome Female medicine.symptom business |
| Zdroj: | Scopus-Elsevier |
| Popis: | The Implantable Gastric Stimulator (IGS(R)), a pacemaker-like device, has been found to be safe and effective to induce and maintain weight loss. The LOSS (Laparoscopic Obesity Stimulation Survey) is a prospective non-randomized trial which enrolled 69 patients involving 11 investigator centers in 5 European Countries. In 19 patients, ghrelin was analyzed.Between January 2002 and December 2003, 69 patients (F/M 49/20), mean age 41 years (18-65) underwent IGS implantation. Mean BMI was 41 (35-57), mean weight 115.0 kg (65-160) and mean excess weight (EW) 52 kg (13-89). The IGS was actived 30 days after implantation. In a subset of 19 patients studied further, 0, 6, and 12 months appetite and satiety score were evaluated and 0 and 6 months ghrelin profile was analyzed.The mean +/- standard error %EWL was: 8.6+/-1.8 at 1 month, 15.8+/-2.3 at 3 months, 17.8+/-2.6 at 6 months, 21.0+/-3.5 at 10 months, and 21.0+/-5.0 at 15 months. There were no intraoperative surgical or long-term complications. 7 intra-operative gastric penetrations occurred, observed by gastroscopy, without sequelae. 1 patient required a reoperation to remove a retained lead needle. In the subset of 19 patients, appetite was reduced and post-prandial and inter-prandial satiety was increased after IGS implantation. In the 19 patients, despite weight reduction, ghrelin did not increase.IGS can be implanted laparoscopically with minimal perioperative complications. Appetite is reduced and satiety is increased after the implantation. Ghrelin levels could be one of the mechanisms explaining weight loss and weight maintenance in IGS patients. If weight loss is maintained, IGS could be considered a good option for selected patients. |
| Databáze: | OpenAIRE |
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