The Multifaceted Roles of Bcl11b in Thymic and Peripheral T Cells: Impact on Immune Diseases
| Autor: | Danielle Califano, Dorina Avram |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
T cell
Immunology Receptors Antigen T-Cell Thymus Gland Biology T-Lymphocytes Regulatory Article Interleukin 21 medicine Animals Humans Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell Precursor Cells T-Lymphoid Tumor Suppressor Proteins ZAP70 CD28 Natural killer T cell Cell biology Repressor Proteins medicine.anatomical_structure Immune System Diseases Natural Killer T-Cells Signal Transduction |
| Zdroj: | The Journal of Immunology. 193:2059-2065 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.1400930 |
| Popis: | The transcription factor Bcl11b is expressed in all T cell subsets and progenitors, starting from the DN2 stage of T cell development, and it regulates critical processes implicated in the development, function, and survival of many of these cells. Among the common roles of Bcl11b in T cell progenitors and mature T cell subsets are the repression of the innate genetic program and, to some extent, expression maintenance of TCR-signaling components. However, Bcl11b also has unique roles in specific T cell populations, suggesting that its functions depend on cell type and activation state of the cell. In this article, we provide a comprehensive review of the roles of Bcl11b in progenitors, effector T cells, regulatory T cells, and invariant NKT cells, as well as its impact on immune diseases. While emphasizing common themes, including some that might be extended to skin and neurons, we also describe the control of specific functions in different T cell subsets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|