Evaluation of safety and efficacy of autologous topical platelet gel vs platelet rich plasma injection in the treatment of venous leg ulcers: A randomized case control study
| Autor: | Lamia H Elgarhy, Amal A El-Ashmawy, Asmaa E. Bedeer, Aya Mohammed Al‐bahnasy |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Chronic wound
medicine.medical_specialty medicine.medical_treatment Dermatology Gastroenterology Varicose Ulcer 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Platelet Saline business.industry Platelet-Rich Plasma Leg Ulcer Case-control study Granulation tissue General Medicine Bandages medicine.anatomical_structure 030220 oncology & carcinogenesis Platelet-rich plasma Case-Control Studies Histopathology medicine.symptom business Immunostaining |
| Zdroj: | Dermatologic therapyREFERENCES. 33(6) |
| ISSN: | 1529-8019 |
| Popis: | Various management options were tried for Chronic venous leg ulcers (VLUs) with no satisfactory results. Platelet-rich plasma (PRP) is promising in enhancing chronic wound healing by releasing various growth factors. We evaluated the safety and efficacy of topical platelet gel (PG) vs PRP injection in treatment of venous leg ulcers. 20 patients were treated with topical PG (group I), 20 patients received PRP injection (group II), and 20 patients were treated with saline dressing and compression as controls (group III) weekly for 6 weeks. Ulcer improvement was evaluated by pressure ulcer scale for healing (PUSH). Histopathological evaluation and immunohistochemical staining using anti-CD34 were performed before and after treatment. There was significant improvement in PUSH score in group (I) and (II) compared to group (III; P value: .001). However, there was no statistically significant difference in improvement between group I and II (P value = .83). However, topical PG was more effective in diabetics and PRP was more effective in long standing fibrosed ulcers. Histopathology showed reduction of the inflammatory cells infiltrates and well-formed granulation tissue with no difference in immunostaining. So, both topical PG and PRP injection were effective, low cost, and safe procedures in enhancing healing of chronic VLUs. |
| Databáze: | OpenAIRE |
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