A randomized controlled trial of vitamin E and selenium on rate of decline in lung function
| Autor: | Kathryn E. Ritchie, Lori M. Minasian, JoAnn A. Hartline, Kathryn B. Arnold, Catherine M. Tangen, Monica L. Bertoia, Patricia A. Cassano, Kristin A. Guertin, Phyllis J. Goodman, Alan R. Kristal, John Crowley, Scott M. Lippman, Eric A. Klein |
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| Rok vydání: | 2015 |
| Předmět: |
Male
and promotion of well-being Antioxidant Forced expiratory flow rate medicine.medical_treatment Respiratory System Physiology Cardiorespiratory Medicine and Haematology Antioxidants Pulmonary function testing law.invention Randomized controlled trial law Vitamin E Lung medicine.diagnostic_test Smoking respiratory system Middle Aged 3. Good health Respiratory Function Tests medicine.anatomical_structure Anesthesia Combination Respiratory Drug Therapy Combination Forced expiratory volume Pulmonary and Respiratory Medicine Spirometry Clinical Trials and Supportive Activities Clinical Sciences chemistry.chemical_element Placebo Selenium Drug Therapy Double-Blind Method Clinical Research Tobacco Complementary and Integrative Health medicine Humans 3.3 Nutrition and chemoprevention Aged Nutrition Tobacco Smoke and Health business.industry Research Prevention Prevention of disease and conditions respiratory tract diseases chemistry Dietary Supplements business Follow-Up Studies |
| Zdroj: | Respiratory research, vol 16, iss 1 Respiratory Research |
| ISSN: | 0024-1865 |
| Popis: | Background The intake of nutrients with antioxidant properties is hypothesized to augment antioxidant defenses, decrease oxidant damage to tissues, and attenuate age-related rate of decline in lung function. The objective was to determine whether long-term intervention with selenium and/or vitamin E supplements attenuates the annual rate of decline in lung function, particularly in cigarette smokers. Methods The Respiratory Ancillary Study (RAS) tested the single and joint effects of selenium (200 μg/d L-selenomethionine) and vitamin E (400 IU/day all rac-α-tocopheryl acetate) in a randomized double-blind placebo-controlled trial. At the end of the intervention, 1,641 men had repeated pulmonary function tests separated by an average of 3 years. Linear mixed-effects regression models estimated the effect of intervention on annual rate of decline in lung function. Results Compared to placebo, intervention had no main effect on either forced expiratory volume in the first second (FEV1) or forced expiratory flow (FEF25–75). There was no evidence for a smoking by treatment interaction for FEV1, but selenium attenuated rate of decline in FEF25–75 in current smokers (P = 0.0219). For current smokers randomized to selenium, annual rate of decline in FEF25–75 was similar to the annual decline experienced by never smokers randomized to placebo, with consistent effects for selenium alone and combined with vitamin E. Conclusions Among all men, there was no effect of selenium and/or vitamin E supplementation on rate of lung function decline. However, current smokers randomized to selenium had an attenuated rate of decline in FEF25–75, a marker of airflow. Trial registration Clinicaltrials.gov identifier: NCT00241865. Electronic supplementary material The online version of this article (doi:10.1186/s12931-015-0195-5) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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