Transient transmission of hepatitis C virus from mothers to newborns
| Autor: | M. Ketzinel-Gilad, E. Granot, R. Hadary, S. L. Colodner, D. Shouval, Eithan Galun |
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| Rok vydání: | 2000 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty DNA Complementary Time Factors Hepatitis C virus Molecular Sequence Data Physiology Hepacivirus medicine.disease_cause Viral Proteins Medical microbiology Pregnancy medicine Humans Pregnancy Complications Infectious Maternal Transmission biology Base Sequence business.industry Infant Newborn virus diseases General Medicine Hepatitis C Sequence Analysis DNA Hepatitis C Antibodies Viral Load medicine.disease digestive system diseases Infectious Disease Transmission Vertical Infectious Diseases Concomitant Immunology biology.protein RNA Viral Female Antibody business Viral load |
| Zdroj: | European journal of clinical microbiologyinfectious diseases : official publication of the European Society of Clinical Microbiology. 19(4) |
| ISSN: | 0934-9723 |
| Popis: | A study was performed in Israel to determine the rate of mother-to-infant HCV transmission in newborns at risk. A group of 22 HCV-infected mothers and their 23 newborns were followed up from early after birth by testing their serum for the presence of HCV antibodies and HCV-RNA. Antibody against HCV was detected in the blood of all newborns immediately after birth, but dropped to low or undetectable levels by 7 months of age. HCV-RNA was detected 2 days after birth in the blood of five infants (22%) but fell to undetectable levels by 6 months. HCV-HVR1 sequence analysis performed in one mother-infant pair on the second day after birth revealed two nucleotide changes. Two months later the same sequence was detected again in the HVR1, suggesting a very low replication rate. Thus, the study showed that vertically transmitted HCV was eliminated in all newborn infants by 6 months after delivery, with concomitant disappearance of HCV antibodies. The mechanism of HCV elimination in newborns at risk remains to be elucidated. |
| Databáze: | OpenAIRE |
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