A case of residual melanoma of the finger
| Autor: | Ita Hadžisejdić, Nives Jonjić, Koviljka Matušan Ilijaš, Boštjan Luzar |
|---|---|
| Jazyk: | chorvatština |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry Melanoma clear cell sarcoma differential diagnosis fluorescence in situ hybridization immunohistochemistry melanoma medicine.disease diferencijalna dijagnoza fluorescentna in situ hibridizacija imunohistokemija melanom svjetlostanični sarkom 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Medicine Immunohistochemistry Clear-cell sarcoma Differential diagnosis business Fluorescence in situ hybridization |
| Zdroj: | Medicina Fluminensis : Medicina Fluminensis Volume 52 Issue 3 |
| ISSN: | 1848-820X 1847-6864 |
| Popis: | Cilj: Cilj je ovog rada prikazati dijagnostički postupak rezidualnog melanoma prsta ruke. Prikaz slučaja: U laboratorij Zavoda za patologiju iz kirurške ambulante primljen je isječak kože četrdesetčetverogodišnjeg muškarca pod dijagnozom tumora četvrtog prsta desne ruke u vidu kupolastog odignuća površine kože najvećeg promjera od 1 centimetra. Lezija je bila boje kože i u cijelosti je preuzeta za patohistološku analizu koja je pokazala da diferencijalno dijagnostički u obzir dolazi melanocitna lezija. S obzirom na izostanak epidermalne komponente lezije bila je potrebna dodatna molekularna analiza za isključivanje svjetlostaničnog sarkoma. Iz naknadno primljenih kliničkih podataka zaključuje se da se zapravo radi o rezidui melanoma koji je prethodno odstranjen bez popratne patohistološke analize. Zaključak: Patohistološka dijagnoza može, općenito, pa tako i u slučaju melanoma, biti otežana zbog nedostatka kliničkih podataka. Suvremena patohistološka dijagnostika ima dobre pomoćne alate za postavljanje točne dijagnoze koja rukovodi daljnji dijagnostički i terapijski protokol pacijenta. No, klinički dermatološki pregled suspektne pigmentne lezije upotpunjen patohistološkom dijagnostikom nezaobilazan je korak, nužan za pravovremeno postavljanje dijagnoze, čime se izbjegava odgađanje početka terapije važne za ishod pacijenta. Objective: The objective of this paper is to present a diagnostic procedure in a case of residual melanoma of the finger. Case report: We received a dome shaped, skin specimen from a forty-four year old man. The skin sample was taken from the fourth finger of his right hand and it was 1 cm in diameter. The skin coloured lesion was serially sectioned and submitted for histopathologic analysis. Microscopic examination showed that it was melanocytic lesion and considering it had no epidermal component, additional molecular analyses were needed to exclude a clear cell sarcoma. A diagnosis of residual melanoma was made, from subsequently received clinical data, however there was no accompanying histopathological analysis from the first excision. Conclusion: A histopathological diagnosis, in general, as well as in the case of melanoma may be difficult due to the lack of clinical data. Contemporary histopathological diagnostics has a good support tools for establishing an accurate diagnosis, which governs the further diagnostic and therapeutic patient’s protocol. However, clinical dermatological examination of doubtful pigmented lesions, complemented by histopathologic diagnostics is a crucial step important for timely diagnosis in order to avoid delay in the therapy which is important for patient’s disease outcome. |
| Databáze: | OpenAIRE |
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