Vaccine efficacy and T helper cell differentiation change with aging
| Autor: | Erica Lorenzo, Sheri M. Eaton, Julie S. Lefebvre, Stephen T. Smiley, April R. Masters, Laura Haynes, Jacob W. Hopkins |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adoptive cell transfer Aging Cellular differentiation Inflammation Lymphocyte Activation 03 medical and health sciences Mice 0302 clinical medicine Research Paper: Gerotarget (Focus on Aging) Orthomyxoviridae Infections antibody medicine Animals biology business.industry Gerotarget Viral Core Proteins RNA-Binding Proteins Cell Differentiation T-Lymphocytes Helper-Inducer Nucleocapsid Proteins Vaccine efficacy medicine.disease Virology influenza vaccination Vaccination Mice Inbred C57BL Pneumonia 030104 developmental biology Oncology Influenza Vaccines Immunology biology.protein Increased inflammatory response medicine.symptom Antibody Th subsets business influenza 030215 immunology |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Influenza and pneumonia are leading causes of death in elderly populations. With age, there is an increased inflammatory response and slower viral clearance during influenza infection which increases the risk of extended illness and mortality. Here we employ a preclinical murine model of influenza infection to examine the protective capacity of vaccination with influenza nucleoprotein (NP). While NP vaccination reduces influenza-induced lung inflammation in young mice, aged mice do not show this reduction, but are protected from influenza-induced mortality. Aged mice do make a significant amount of NP-specific IgG and adoptive transfer experiments show that NP antibody can protect from death but cannot reduce lung inflammation. Furthermore, young but not aged vaccinated mice generate significant numbers of NP-specific T cells following subsequent infection and few of these T cells are found in aged lungs early during infection. Importantly, aged CD4 T cells have a propensity to differentiate towards a T follicular helper (Tfh) phenotype rather than a T helper 1 (Th1) phenotype that predominates in the young. Since Th1 cells are important in viral clearance, reduced Th1 differentiation in the aged is critical and could account for some or all of the age-related differences in vaccine responses and infection resolution. |
| Databáze: | OpenAIRE |
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