Analysis of Phenolic Components and Related Biological Activities of 35 Apple (Malus pumila Mill.) Cultivars

Autor: Jinping Cao, Xin Li, Tailin Zhu, Bo Song, Qiong Lin, Yue Wang, Xiao Liang, Sijia Yang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Malus
Antioxidant
DPPH
medicine.medical_treatment
phenolics
Phytochemicals
Pharmaceutical Science
apple
biological activity
engineering.material
High-performance liquid chromatography
Article
Antioxidants
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
chemistry.chemical_compound
0404 agricultural biotechnology
Phenols
lcsh:Organic chemistry
Cell Line
Tumor
Drug Discovery
medicine
Humans
Cultivar
Food science
Physical and Theoretical Chemistry
030304 developmental biology
0303 health sciences
biology
Chemistry
Plant Extracts
Pulp (paper)
Organic Chemistry
Polyphenols
food and beverages
Biological activity
04 agricultural and veterinary sciences
Hep G2 Cells
biology.organism_classification
040401 food science
Antineoplastic Agents
Phytogenic
Proanthocyanidin
Chemistry (miscellaneous)
Fruit
high-resolution mass spectroscopy (HRMS)
engineering
Molecular Medicine
Zdroj: Molecules
Volume 25
Issue 18
Molecules, Vol 25, Iss 4153, p 4153 (2020)
ISSN: 1420-3049
DOI: 10.3390/molecules25184153
Popis: Apple (Malus pumila Mill.) is a popular fruit with high economic values and various biological activities that are beneficial to human health. In this study, 35 apple cultivars were collected and were evaluated for their basic quality indexes, phenolic compositions, antioxidant activity, anti-tumour, and anti-diabetic activities. The compositions of phenolics were detected by using high-performance liquid chromatography (HPLC) and high-resolution mass spectroscopy (HRMS) assays. The antioxidant activities of peel and pulp extracts from 35 apple cultivars were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay and ferric reducing antioxidant power (FRAP) assay. Results showed that the contents of phenolic acids and proanthocyanidins showed significant correlations with the antioxidant activities. Phenolic-rich extracts significantly inhibited HepG2 cell proliferation, with the inhibition activity varied significantly between cultivars. &lsquo
Gold Delicious&rsquo
pulp extract, &lsquo
Xiboliyabaidian&rsquo
peel and pulp extracts showed protective effects on H2O2-induced injury of human umbilical vein endothelial cells (HUVEC). &lsquo
Red Fuji&rsquo
peel extract, &lsquo
peel and pulp extracts, as well as &lsquo
peel extract, significantly increased glucose consumption of HepG2 cells, in a dose-dependent manner. This research may provide theoretical guidance for further nutritional investigation of the apple resources.
Databáze: OpenAIRE
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