Herpes Labialis, Chlamydophila pneumoniae, Helicobacter pylori, and Cytomegalovirus Infections and Risk of Dementia: The Framingham Heart Study
| Autor: | Sudha Seshadri, Joel Salinas, Adrienne O’Donnell, Alexa S. Beiser, Eduardo Marques Zilli, Mini E. Jacob, Mitzi M. Gonzales, Hugo J. Aparicio |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Cytomegalovirus Herpesvirus 1 Human Neuropsychological Tests medicine.disease_cause Risk Assessment Article Helicobacter Infections Framingham Heart Study Alzheimer Disease Internal medicine medicine Humans Dementia Serologic Tests Longitudinal Studies Aged Proportional Hazards Models Herpes Labialis Framingham Risk Score Helicobacter pylori biology business.industry General Neuroscience Incidence (epidemiology) Brain General Medicine Chlamydophila pneumoniae medicine.disease biology.organism_classification Magnetic Resonance Imaging Causality Psychiatry and Mental health Clinical Psychology Cytomegalovirus Infections Cohort Female Geriatrics and Gerontology business |
| Zdroj: | J Alzheimers Dis |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: An association between chronic infectious diseases and development of dementia has been suspected for decades, based on the finding of pathogens in postmortem brain tissue and on serological evidence. However, questions remain regarding confounders, reverse causality, and how accurate, reproducible and generalizable those findings are. Objective: Investigate whether exposure to Herpes simplex (manifested as herpes labialis), Chlamydophila pneumoniae (C. pneumoniae), Helicobacter pylori (H. pylori), and cytomegalovirus (CMV) modifies the risk of dementia in a populational cohort. Methods: Questionnaires regarding incidence of herpes infections were administered to Original Framingham Study participants (n = 2,632). Serologies for C. pneumoniae, H. pylori, and CMV were obtained in Original (n = 2,351) and Offspring cohort (n = 3,687) participants. Participants are under continuous dementia surveillance. Brain MRI and neuropsychological batteries were administered to Offspring participants from 1999–2005. The association between each infection and incident dementia was tested with Cox models. Linear models were used to investigate associations between MRI or neuropsychological parameters and serologies. Results: There was no association between infection serologies and dementia incidence, total brain volume, and white matter hyperintensities. Herpes labialis was associated with reduced 10-year dementia risk (HR 0.66, CI 0.46–0.97), but not for the duration of follow-up. H. pylori antibodies were associated with worse global cognition (β –0.14, CI –0.22, –0.05). Conclusion: We found no association between measures of chronic infection and incident dementia, except for a reduction in 10-year dementia risk for patients with herpes labialis. This unexpected result requires confirmation and further characterization, concerning antiviral treatment effects and capture of episodes. |
| Databáze: | OpenAIRE |
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