Clinical correlates of cerebral white matter abnormalities in patients with Parkinson's disease

Autor: Bastiaan R. Bloem, Marjolein B. Aerts, Anouke van Rumund, Mayra I. Bergkamp, Daniel J. van Wamelen, Rianne A. J. Esselink, Edo Richard, Bibet L. ten Harmsen, Frederick J. A. Meijer
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Parkinson's disease
Dopamine Agents
Disease
Autonomic Nervous System
Severity of Illness Index
Hypotension
Orthostatic
03 medical and health sciences
Orthostatic vital signs
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Internal medicine
Basal ganglia
medicine
Humans
Cognitive Dysfunction
Stage (cooking)
Cognitive decline
Aged
Retrospective Studies
Aged
80 and over
medicine.diagnostic_test
business.industry
Parkinson Disease
Magnetic resonance imaging
Middle Aged
Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3]
medicine.disease
Magnetic Resonance Imaging
White Matter
Hyperintensity
Cross-Sectional Studies
030104 developmental biology
Neurology
Female
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Zdroj: Parkinsonism & Related Disorders, 49, 28-33
Parkinsonism & Related Disorders, 49, pp. 28-33
ISSN: 1353-8020
DOI: 10.1016/j.parkreldis.2017.12.029
Popis: Objective To determine if autonomic dysfunction, cognitive disorders or axial disability are associated with white matter lesions (WML) in Parkinson disease (PD). Methods We performed a retrospective cross-sectional review study on 204 consecutive PD patients who underwent cerebral MRI in our center between January 2012 and July 2016. For each patient, we scored the severity of WML and PV (periventricular) WML using the Fazekas score and using the ARWMC scale for WML and BG (basal ganglia) and clinical characteristics such as neurogenic orthostatic hypotension and cognitive function. Results 204 PD patients were included of whom n = 53 (26.0%) had neurogenic orthostatic hypotension (nOH). The presence of nOH was significantly associated with the severity of WML as defined by the Fazekas score and the ARWMC scale. An ordinal regression model confirmed this association with an OR of 0.41 (95% CI 0.18–0.92: p = .03) and an OR of 0.39 (95% CI 0.17–0.88: p = .02). There were no significant associations between WML and other co-variables, including hypertension, dopaminergic medication use, Hoehn and Yahr stage, gender and cognitive decline. Conclusion The presence of nOH is associated with WML severity in PD patients.
Databáze: OpenAIRE
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