Naloxone Interaction with Some CNS Depressants
| Autor: | Mo Yin Chan |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Time Factors medicine.drug_class Chloral hydrate (+)-Naloxone Pharmacology Hypnotic Mice Combined treatment Animals Medicine Drug Interactions Ketamine Mice Inbred ICR Naloxone business.industry Narcotic antagonist Central Nervous System Depressants General Medicine Drug interaction Phenobarbital Anesthesia Cns depressants Sleep business medicine.drug |
| Zdroj: | Pharmacology. 31:294-297 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000138135 |
| Popis: | Mice were either pretreated with naloxone (10 mg/kg i.p.) and then injected with a hypnotic, or given a similar dose of naloxone simultaneously with a hypnotic (combination treatment). Neither the naloxone pretreatment nor the combination treatment changed the time of on-set or the sleeping duration of urethane, chloral hydrate or ketamine. However, the naloxone pretreatment markedly decreased the on-set time and prolonged the sleeping duration of phenobarbitone and barbitone; naloxone in combination prolonged the sleeping duration of pentobarbitone, phenobarbitone and barbitone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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