Early Gastrointestinal Regulatory Peptide Response to Intestinal Resection in the Rat Is Stimulated by Enteral Glutamine Supplementation
| Autor: | Jörgen Larsson, Thomas E. Adrian, P. Staab, Mikael Wirén, Urban Arnelo, Johan Permert |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Glutamine Glucagon-Like Peptides Enteroglucagon Regulatory peptide Enteral administration Gastrointestinal Hormones Rats Sprague-Dawley Insulin-Like Growth Factor II Epidermal growth factor Internal medicine Animals Medicine Peptide YY Insulin-Like Growth Factor I Intestinal Mucosa Epidermal Growth Factor business.industry Gastroenterology Transforming Growth Factor alpha Rats Intestines Endocrinology Glutamine supplementation Surgery Intestinal resection business |
| Zdroj: | Digestive Surgery. 16:197-203 |
| ISSN: | 1421-9883 0253-4886 |
| DOI: | 10.1159/000018727 |
| Popis: | Background: Intestinal resection stimulates the synthesis and release of gastrointestinal peptides that regulate the growth and adaptation of the mucosa. Luminal nutrients are necessary for optimal proliferation and glutamine is the preferential nutrient to the small bowel. The interplay between glutamine and regulatory peptides could be important in treating short bowel syndrome. Methods: 63 Sprague-Dawley rats were divided into 3 groups: resection; transection, or controls. After intestinal resection animals were orally fed either a diet without glutamine or a glutamine-supplemented diet for 2 days. Transected animals and controls without prior surgery were fed the same two diets. Epidermal growth factor (EGF), transforming growth factor-α, insulin-like growth factors I and II (IGF-I and IGF-II), peptide YY (PYY), and enteroglucagon were analyzed in mucosa from the proximal jejunum, distal ileum as well as in portal plasma when the animals were euthanized 72 h after surgery. Results: Intestinal resection resulted in an early increase in portal plasma concentrations of PYY, EGF, enteroglucagon, and mucosal IGF-II and EGF content that were significant in glutamine-treated animals. Glutamine significantly increased PYY in portal blood after resection (p < 0.05). Conclusion: Glutamine could be of importance for the functional adaptation of residual small bowel mucosa by increasing PYY release. |
| Databáze: | OpenAIRE |
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