Campylobacter jejuni targets immunoglobulin-like receptor LMIR5
| Autor: | Vongsavanh Phongsisay |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
NFATC Transcription Factors
biology TREM2 Immunology Membrane Proteins Signal transducing adaptor protein NFAT bacterial infections and mycoses biology.organism_classification Campylobacter jejuni Virology Microbiology Molecular Weight Immune system Immunopathology biology.protein Humans RNA Receptors Immunologic Antibody Receptor Glycoconjugates Molecular Biology Adaptor Proteins Signal Transducing |
| Zdroj: | Molecular Immunology. 63:574-578 |
| ISSN: | 0161-5890 |
| DOI: | 10.1016/j.molimm.2014.07.024 |
| Popis: | Campylobacter jejuni causes gastroenteritis and Guillain-Barré syndrome. Host immunity plays an important role in the disease pathogenesis; however, little is known about the immune receptors for C. jejuni. We report here that C. jejuni targets C-type lectin (SIGNR1, SIGNR3) and immunoglobulin-like receptors (TREM2, TREM3, LMIR5, LMIR8). Among these, C. jejuni interacted preferentially with LMIR5, which was selected for further verification using reporter cells. LMIR5 ligation by C. jejuni activated transcriptional factor NFAT through adaptor protein DAP12. Furthermore, LMIR5 activators were identified as protein components, RNA-associated proteins, and 150-kDa high-molecular-weight glycoconjugates. This finding discloses potential receptors that might link C. jejuni to immunopathology. |
| Databáze: | OpenAIRE |
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