Nebulin, a multi-functional giant
| Autor: | Miensheng Chu, Christopher T. Pappas, Carol C. Gregorio |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology Muscle Proteins The Cytoskeleton macromolecular substances Aquatic Science Biology Sarcomere Filamentous actin Protein filament 03 medical and health sciences Nebulin medicine Animals Humans Disease Molecular Biology Ecology Evolution Behavior and Systematics Actin Skeletal muscle Actin Cytoskeleton Crystallography 030104 developmental biology medicine.anatomical_structure Insect Science Mutation biology.protein Biophysics Animal Science and Zoology medicine.symptom Myofibril Protein Binding Muscle contraction |
| Zdroj: | Journal of Experimental Biology. 219:146-152 |
| ISSN: | 1477-9145 0022-0949 |
| Popis: | Efficient muscle contraction in skeletal muscle is predicated on the regulation of actin filament lengths. In one long-standing model that was prominent for decades, the giant protein nebulin was proposed to function as a ‘molecular ruler’ to specify the lengths of the thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|