Intestinal Permeability in Piglets During Transmissible Gastroenteritis
| Autor: | H. J. A. Egberts, J. M. V. M. Mouwen, L. Vellenga, J. E. Dijk |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Swine animal diseases media_common.quotation_subject Horseradish peroxidase Permeability Pathology and Forensic Medicine Jejunum fluids and secretions medicine Animals Intestinal Mucosa Villous atrophy media_common Intestinal permeability Microvilli integumentary system General Veterinary biology Gastroenteritis Transmissible of Swine Inoculation Appetite medicine.disease Small intestine Specific Pathogen-Free Organisms Intestines medicine.anatomical_structure Vomiting biology.protein Atrophy medicine.symptom |
| Zdroj: | Journal of Veterinary Medicine Series A. 38:157-164 |
| ISSN: | 1439-0442 0931-184X |
| DOI: | 10.1111/j.1439-0442.1991.tb00997.x |
| Popis: | Summary Macromolecular permeability of the small intestine was tested in seven three-week-old piglets infected with porcine transmissible gastroenteritis virus (TGE-strain Miller). Fourteen hours after the infection, the piglets showed loss of appetite and a profuse diarrhoea. In some animals vomiting occurred somewhat earlier. Macromolecular permeability was tested morphologically by injecting horseradish peroxidase (MW = 40,000 Da) into the jejunal lumen just distally to the Treitz' ligament in two piglets at 12 hours and in five piglets at 48 hours after the inoculation in comparison with two control piglets. After a period of 20 minutes, small segments of jejunum were taken for stereomicroscopical, histological and ultrastructural investigations. An increased permeability for HRP together with a severe, hyper-regenerative villous atrophy was observed in the TGE-infected piglets at 48 hours after the inoculation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|