Malignant teratoid medulloepithelioma with retinoblastic and rhabdomyoblastic differentiation
| Autor: | Thomas C. Lee, Don S. Minckler, A. Linn Murphree, James B. Earl |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Retinal Neoplasms Population Biopsy Fine-Needle Gestational Age Persistent Hyperplastic Primary Vitreous Eye Enucleation Diagnosis Differential chemistry.chemical_compound Antigen Rhabdomyosarcoma Biomarkers Tumor Medicine Humans education Myogenin Ultrasonography education.field_of_study business.industry Retinoblastoma Skeletal muscle Infant Cell Differentiation medicine.disease Neoplasms Neuroepithelial Ophthalmology medicine.anatomical_structure Myoglobin chemistry Pediatrics Perinatology and Child Health Immunohistochemistry Desmin Female business Tomography X-Ray Computed |
| Zdroj: | Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus. 17(3) |
| ISSN: | 1528-3933 |
| Popis: | We describe an unusual case of malignant teratoid medulloepithelioma in which distinct populations of tumor cells with different immunohistochemical staining patterns existed within the same eye. A neuroblastic population exhibited atypical features of retinoblastoma, including organization into pseudo-Flexner-Wintersteiner and Homer-Wright rosettes. Other populations evolved in strikingly different patterns, with large fields of cells resembling astrocytes and intervening streams of spindle cells that suggested smooth muscle. The spindle cell population was negative for smooth muscle antigen but stained positively for desmin, myoglobin, and myogenin. Under high magnification, the desmin, myoglobin, and myogenin-staining cells exhibited striations consistent with skeletal muscle differentiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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