The Specificity of the Persistent IgM Neutralizing Antibody Response in Zika Virus Infections among Individuals with Prior Dengue Virus Exposure
| Autor: | Mars Stone, Karen L. Boroughs, Brad J. Biggerstaff, Kimberly M. Anderson, Kalanthe Horiuchi, Amanda E. Calvert, Michael P. Busch, Yee Tsuey Ong, Graham Simmons, Claire Y.-H. Huang |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Vaccine evaluation media_common.quotation_subject viruses Dengue virus Cross Reactions medicine.disease_cause Antibodies Viral Neutralization Dengue fever Zika virus Dengue medicine Animals Humans Neutralizing antibody Immunoassays media_common biology business.industry Zika Virus Infection Convalescence Zika Virus Dengue Virus medicine.disease biology.organism_classification Virology Antibodies Neutralizing Immunoglobulin M biology.protein Antibody business |
| Zdroj: | J Clin Microbiol |
| ISSN: | 1098-660X |
| Popis: | Dengue viruses (DENV) and Zika virus (ZIKV) are related mosquito-borne flaviviruses with similar disease manifestations, vector ecologies, and geographic ranges. The ability to differentiate these viruses serologically is vital due to the teratogenic nature of ZIKV and the potential confounding of preexisting cross-reactive anti-DENV antibodies. Here, we illustrate the kinetics of the IgM neutralizing antibody (NAb) response using longitudinal samples ranging from acute ZIKV infection to late convalescence from individuals with evidence of prior DENV infection. By serially depleting antibody isotypes prior to the neutralization assay, we determined that IgM contributes predominantly to ZIKV neutralization and is less cross-reactive than the IgG NAb. The IgM NAb peaked around 14 days (95% confidence interval [95% CI], 13 to 15) and had a median duration of 257 days (95% CI, 133 to 427). These results demonstrate the persistence of IgM NAb after ZIKV infection and imply its potential role in diagnosis, vaccine evaluation, serosurveillance, and research on flavivirus-host interactions. |
| Databáze: | OpenAIRE |
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