Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology
| Autor: | Natalja Genina, Christos S Katsiotis, Johan Boetker, Jukka Rantanen, Georgios K. Eleftheriadis, Dimitrios G. Fatouros |
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| Rok vydání: | 2020 |
| Předmět: |
Technology
Materials science injection molding Polymers Pharmaceutical Science 3D printing Nanotechnology Fused filament fabrication automated filling 02 engineering and technology 030226 pharmacology & pharmacy Excipients 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems biologics Inkjet printing electrospinning inkjet printing business.industry 021001 nanoscience & nanotechnology hybrid systems Pharmaceutical Preparations Hybrid system Drug delivery Printing Three-Dimensional fused filament fabrication 0210 nano-technology business |
| Zdroj: | Eleftheriadis, G K, Katsiotis, C S, Genina, N, Boetker, J, Rantanen, J & Fatouros, D G 2020, ' Manufacturing of hybrid drug delivery systems by utilizing the fused filament fabrication (FFF) technology ', Expert Opinion on Drug Delivery, vol. 17, no. 8, pp. 1063-1067 . https://doi.org/10.1080/17425247.2020.1776260 |
| ISSN: | 1744-7593 |
| DOI: | 10.1080/17425247.2020.1776260 |
| Popis: | The potential of fused filament fabrication (FFF) for the administration of active pharmaceutical compounds is a recent approach to develop complex and custom-made drug delivery systems (DDSs). However, the FFF technology is characterized by certain limitations, which are associated with the nature of the process, i.e., the required mechanical properties of the feedstock, as well as the thermal stability of the incorporated polymers, excipients and active compounds. Thus, hybrid DDSs have been recently introduced, to overcome these boundaries. The concept of these systems is defined by the effective coupling of FFF with conventional manufacturing technologies, as a novel pathway to expand the available pool of raw materials and pharmaceutical applications of FFF. |
| Databáze: | OpenAIRE |
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