Clinicopathological significance and potential drug target of O6-methylguanine-DNA methyltransferase in colorectal cancer: a meta-analysis
| Autor: | Le-chi Ye, Zong-Jing Chen, Nian-zhao Chen, Chen-guo Zheng, Chun Jin |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty Guanine Colorectal cancer Colorectal adenoma Bioinformatics O(6)-Methylguanine-DNA Methyltransferase Internal medicine medicine Humans Stage (cooking) Promoter Regions Genetic neoplasms Neoplasm Staging business.industry Hazard ratio Microsatellite instability O-6-methylguanine-DNA methyltransferase General Medicine Odds ratio DNA Methylation medicine.disease Prognosis digestive system diseases Gene Expression Regulation Neoplastic Meta-analysis Mutation business Colorectal Neoplasms |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(8) |
| ISSN: | 1423-0380 |
| Popis: | Emerging evidence indicates that O(6)-methylguanine-DNA methyltransferase (MGMT) is a candidate for tumor suppression in several types of human tumors including colorectal cancer (CRC). However, the correlation between MGMT hypermethylation and clinicopathological characteristics of CRC remains unclear. In this study, we conducted a systematic review and meta-analysis to quantitatively evaluate the effects of MGMT hypermethylation on the incidence of CRC and clinicopathological characteristics. A comprehensive literature search was done from Web of Science, the Cochrane Library Database, PubMed, EMBASE, CINAHL, and the Chinese Biomedical Database for related research publications written in English and Chinese. Methodological quality of the studies was also evaluated. Analyses of pooled data were performed with Review Manager 5.2. Odds ratio (OR) and hazard ratio (HR) were calculated and summarized, respectively. Final analysis from 28 eligible studies was performed. MGMT hypermethylation is found to be significantly higher in CRC than in normal colorectal mucosa, the pooled OR from 13 studies including 1085 CRC and 899 normal colorectal mucosa, OR = 6.04, 95 % confidence interval (CI) = 4.69-7.77, p |
| Databáze: | OpenAIRE |
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