Isatin derivatives with activity against apoptosis-resistant cancer cells†
| Autor: | Igor V. Magedov, Dominic N McBrayer, Nikolai M. Evdokimov, Alexander Kornienko |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Isatin
Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents Apoptosis 01 natural sciences Biochemistry Article 03 medical and health sciences chemistry.chemical_compound Structure-Activity Relationship 0302 clinical medicine Cell Line Tumor Neoplasms Drug Discovery Structure–activity relationship Humans Methylene Molecular Biology Cell Proliferation Dose-Response Relationship Drug Molecular Structure 010405 organic chemistry Chemistry Cell growth Organic Chemistry Small molecule 0104 chemical sciences 030220 oncology & carcinogenesis Cancer cell Molecular Medicine Indirubin Drug Screening Assays Antitumor |
| Popis: | In a search of small molecules active against apoptosis-resistant cancer cells, a series of isatin-based heterocyclic compounds were synthesized and found to inhibit proliferation of cancer cell lines resistant to apoptosis. The synthesis of these compounds involved a condensation of commercially available, active methylene heterocycles with isatin proceeding in moderate to excellent yields. The heterocyclic scaffolds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with dismal prognoses. |
| Databáze: | OpenAIRE |
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