Comparative effects of simvastatin and pravastatin on cholesterol synthesis in patients with primary hypercholesterolemia
| Autor: | Claude Colette, Christine Feillet, Louis Monnier, Bernard Descomps, AndréCrastes de Paulet, Christine Percheron, Michel Farnier |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Cholesterol synthesis Simvastatin medicine.medical_specialty Adolescent medicine.medical_treatment Mevalonic Acid Lathosterol Hyperlipoproteinemia Type II chemistry.chemical_compound Double-Blind Method Internal medicine polycyclic compounds Humans Medicine Lovastatin Enzyme Inhibitors Triglycerides Aged Pravastatin Chemotherapy Cross-Over Studies business.industry Cholesterol Anticholesteremic Agents Cholesterol HDL nutritional and metabolic diseases Cholesterol LDL Middle Aged Crossover study Apolipoproteins Treatment Outcome Endocrinology Liver chemistry Concomitant Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Atherosclerosis. 118:251-258 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/0021-9150(95)05611-4 |
| Popis: | The effects of simvastatin and pravastatin on cholesterol biosynthesis were compared in 26 hypercholesterolemic patients who were randomly allocated to either simvastatin or pravastatin treatment (20 mg once daily) for 6 weeks in a crossover trial. Serum total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) lathosterol (latho) concentrations and lathosterol/cholesterol (latho/chol) ratios (the latter two are considered as reliable indices of whole body cholesterol synthesis) were evaluated at the beginning and end of each therapeutic sequence. Reductions in TC and LDL-C were more pronounced (P < 0.001) with simvastatin (TC = -28.0%, LDL-C = -35.6%) than with pravastatin (TC = -19.6%, LDL-C = -25.2%). These results were associated with concomitant decreases in both latho concentrations (-59.0% with simvastatin and -37.0% with pravastatin) and latho/chol ratios (-43.0% with simvastatin and -20.3% with pravastatin). Simvastatin resulted in more marked diminutions of latho concentrations (P < 0.01) and latho/chol ratios (P < 0.05) than pravastatin. These results suggest that the better efficacy of simvastatin on serum cholesterol and LDL cholesterol might result in part from a greater inhibitory action of simvastatin on cholesterol synthesis compared with that of pravastatin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect