Contrast-to-noise ratio in functional MRI of relative cerebral blood volume with sprodiamide injection
| Autor: | Sarah F. Kulke, Thomas J. Brady, A. Gregory Sorensen, Michael H. Lev, Bruce R. Rosen, Robert M. Weisskoff, Jerry L. Boxerman, Brad R. Buchbinder |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Sprodiamide Contrast Media Sensitivity and Specificity White matter Contrast-to-noise ratio Protocol design Reference Values medicine Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Practical implications Aged Analysis of Variance Brain Mapping Blood Volume medicine.diagnostic_test Dose-Response Relationship Drug Chemistry business.industry Brain Magnetic resonance imaging Middle Aged Pentetic Acid Image Enhancement Magnetic Resonance Imaging Cerebral blood volume medicine.anatomical_structure Cerebral blood flow Female Nuclear medicine business |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 7(3) |
| ISSN: | 1053-1807 |
| Popis: | The purpose of this study was to investigate the dependence of contrast-to-noise ratio (CNR) on the dose and rate of sprodiamide injection in magnetic resonance relative cerebral blood volume (rCBV) imaging. rCBV maps for 35 normal volunteers were constructed from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of sprodiamide. Doses of .1, .2, and .3 mmol/kg, at rates of 2 ml/second and 5 ml/second, were tested. CNRs and blood/volume ratios of gray to white matter were computed. CNR depended on dose (P < .0001) but was independent of injection rate (P < .69). rCBV ratios of gray to white matter were dose independent (P < .38) and rate independent (P < .97). The dependence of CNR on dose, but not injection rate, has practical implications in optimal protocol design. The independence of gray/white ratios supports the theory underlying the generation of rCBV maps. |
| Databáze: | OpenAIRE |
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