Investigation of the behavioral and neurochemical effects of monosodium glutamate on neonatal rats

Autor: Eyup Başkale, Ayşen Çetin Kardeşler
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Monosodium glutamate
Dopamine
latent period
open field test
Wistar rat
animal behavior
chemistry.chemical_compound
0302 clinical medicine
Neurochemical analysis
Catecholamines
4 aminobutyric acid
newborn
radial arm maze test
Sodium Glutamate
catecholamine blood level
rat
animal
Behavioral analysis
gamma-Aminobutyric Acid
Cerrahi
Behavior
Animal
dopamine blood level
drug effect
Glutamate receptor
04 agricultural and veterinary sciences
General Medicine
040401 food science
Epinephrine
drug dose comparison
catecholamine
Animals
Animals
Newborn
Behavior
Animal/*drug effects
Brain Chemistry/*drug effects
Catecholamines/analysis
Dopamine/analysis
Glutamic Acid/analysis
Maze Learning/drug effects
Rats
Rats
Wistar
Sodium Glutamate/*pharmacology
gamma-Aminobutyric Acid/analysis
medicine.drug
glutamate sodium
medicine.medical_specialty
Dose
animal experiment
neurochemistry
Glutamic Acid
behavioral science
Article
Monosodium glutamate
behavioral analysis
neurochemical analysis
03 medical and health sciences
Norepinephrine
0404 agricultural biotechnology
Neurochemical
Internal medicine
medicine
drug mechanism
controlled study
maze test
Maze Learning
Brain Chemistry
nonhuman
business.industry
animal model
behavioral analysis
neurochemical analysis
enzyme linked immunosorbent assay
Endocrinology
chemistry
Catecholamine
business
030217 neurology & neurosurgery
Zdroj: Volume: 47, Issue: 3 1002-1011
Turkish Journal of Medical Sciences
ISSN: 1300-0144
1303-6165
Popis: Background/aim: The objective of this study was to investigate and analyze the behavioral and neurochemical effects of monosodium glutamate (MSG) injections at various and subsequent dosages on male Wistar rats during the neonatal period.
Materials and methods: In order to determine the behavioral and neurochemical effects of MSG, the experiment was implemented on neonatal male Wistar rats and the test was repeated for various MSG dosages. After completing the experiment, additionally, levels of dopamine, GABA, catecholamine (dopamine, noradrenaline, and adrenaline) and glutamate in the brain cells of the decapitated rats were also measured using the ELISA method.
Results: Considering the results of the behavioral test, when we compared the test values of the control group with the values of the MSG-injected groups we noted that there were significant differences in the statistical figures obtained. Additionally, we found that the statistical figures of some neurochemical parameters were also significantly different when we compared the values of the MSG group with the control values.
Conclusion: MSG injection has a clear effect on the neurochemical parameters, learning memory, and locomotor activities of rats.
Databáze: OpenAIRE
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