BDNF and NT3 extend the critical period for developmental climbing fibre plasticity
| Autor: | Adrian J. Bower, Rachel M. Sherrard |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Aging
Cerebellum Period (gene) Central nervous system Amidines Cell Count Cytochrome c Group Olivary Nucleus Biology Neurotrophin 3 medicine Animals Rats Wistar Fluorescent Dyes Denervation Brain-derived neurotrophic factor Afferent Pathways Neuronal Plasticity Dose-Response Relationship Drug Brain-Derived Neurotrophic Factor General Neuroscience Axons Nerve Regeneration Rats medicine.anatomical_structure Animals Newborn nervous system Cerebellar cortex biology.protein Neuroscience Reinnervation Neurotrophin |
| Zdroj: | Neuroreport. 12:2871-2874 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200109170-00023 |
| Popis: | The effect on neonatal brain plasticity of two neurotrophins, brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), was studied using the rat olivocerebellar projection as a model. Unilateral transection of climbing fibres (CFs) in the rat before postnatal day 7 induces reinnervation of the deafferented hemicerebellum, but this does not occur if the transection is performed after postnatal day 10. Eleven-day-old day rats underwent unilateral CF transection followed by neurotrophin injection into the denervated cerebellar cortex 24 h later. The exogenous neurotrophins induced CF reinnervation of the denervated hemicerebellum. However BDNF was more efficacious than NT-3. Thus two neurotrophins can extend the window of neonatal brain plasticity, therefore suggesting potential therapeutic use after brain trauma. |
| Databáze: | OpenAIRE |
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