Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

Autor: Laura Bonfanti, Giuseppe Lippi, Gianfranco Cervellin, Alessandra Picanza
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Potassium
D-dimer
atrial fibrillation
cardiovascular disease
Gastroenterology
Hipopotassemia
Reference Values
Risk Factors
Atrial Fibrillation
Tromboembolia
Sinus rhythm
Atrial fibrillation
Venous Thromboembolism
Middle Aged
Hypokalemia
Cardiovascular Diseases
Fibrilação Atrial
Acute Disease
Female
Potassio
medicine.symptom
Cardiology and Cardiovascular Medicine
medicine.medical_specialty
chemistry.chemical_element
Risk Assessment
Statistics
Nonparametric
Fibrin Fibrinogen Degradation Products
Internal medicine
Tromboembolism
medicine
Humans
Fibrinogênio / metabolismo
Aged
Retrospective Studies
Fibrinogen / metabolism
business.industry
Original Articles
Emergency department
medicine.disease
Endocrinology
Serum potassium
chemistry
lcsh:RC666-701
Relative risk
business
Zdroj: Arquivos Brasileiros de Cardiologia, Vol 104, Iss 3, Pp 181-184 (2015)
Arquivos Brasileiros de Cardiologia
Arquivos Brasileiros de Cardiologia v.104 n.3 2015
Sociedade Brasileira de Cardiologia (SBC)
instacron:SBC
ISSN: 1678-4170
Popis: Background: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. Objective: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). Methods: To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Results: Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. Conclusions: The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.
Databáze: OpenAIRE
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