Association of Preoperative Radiation Effect with Tumor Angiogenesis and Vascular Endothelial Growth Factor in Oral Squamous Cell Carcinoma
| Autor: | Mariko Mihara, Satoru Shintani, Yuuji Nakahara, Tomohiro Matsumura, Yoshiya Ueyama, Nagaaki Terakado, Akihisa Kiyota |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A Cancer Research Pathology medicine.medical_specialty Intratumoral microvessel density Angiogenesis medicine.medical_treatment Endothelial Growth Factors Radiosensitivity Neovascularization chemistry.chemical_compound Preoperative Care Biomarkers Tumor medicine Carcinoma Humans Aged Aged 80 and over Mouth neoplasm Lymphokines Neovascularization Pathologic Vascular Endothelial Growth Factors business.industry Oral cancer Middle Aged medicine.disease Radiation therapy Vascular endothelial growth factor Vascular endothelial growth factor A Oncology Epidermoid carcinoma chemistry Carcinoma Squamous Cell Female Mouth Neoplasms medicine.symptom business Rapid Communication |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| DOI: | 10.1111/j.1349-7006.2000.tb00884.x |
| Popis: | This study examined the relationship between tumor angiogenesis and the radiation-induced response, evaluated based on pathological changes, in oral squamous cell carcinoma patients treated with preoperative radiation therapy. Forty-one cases of squamous cell carcinoma treated with preoperative radiation therapy were investigated. Tumor angiogenesis was assessed by scoring the intratumor microvessel density (IMVD). Expression of vascular endothelial growth factor (VEGF) was also evaluated before and after preoperative radiotherapy. There was no correlation between IMVD in the specimens before therapy and the pathological response to radiation therapy. However, radiation therapy decreased IMVD in the specimens after therapy. A significant association was observed between VEGF expression and resistance to radiation therapy: only 4 of the 21 patients whose tumors exhibited a high level (2 + or 3 + ) of VEGF staining experienced a major (3 + or 4 + ) pathological response to radiation therapy. Furthermore, an increasing level of VEGF expression after radiation therapy was observed in non-effective (0 to 2 + ) response cases. These results suggest that VEGF expression and the induction of this protein are related to radiosensitivity and could be used to predict the effects of preoperative radiation therapy on oral squamous cell carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text