Texture Analysis of T2-Weighted MR Images to Assess Acute Inflammation in Brain MS Lesions
| Autor: | Michoux, Nicolas, Guillet, Alain, Rommel, Denis, Mazzamuto, Giosué, Sindic, Christian, Duprez, Thierry, Lenglet, Christophe |
|---|---|
| Přispěvatelé: | UCL - SSH/IMMAQ/SMCS - Support en méthodologie et calcul statistique (plate-forme technologique), UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de radiologie, UCL - (SLuc) Service de neurologie, CISM:CECI - CISM:CECI, UCL - SSS/IONS/NEUR - Clinical Neuroscience |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Multiple Sclerosis lcsh:Medicine Fluid-attenuated inversion recovery Pattern Recognition Automated White matter Partial least squares regression medicine Humans Effective diffusion coefficient lcsh:Science Inflammation Multidisciplinary medicine.diagnostic_test business.industry lcsh:R Brain Magnetic resonance imaging Linear discriminant analysis Magnetic Resonance Imaging Hyperintensity Radiographic Image Enhancement medicine.anatomical_structure ROC Curve Blood-Brain Barrier lcsh:Q Nuclear medicine business Research Article Diffusion MRI |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 12, p e0145497 (2015) PLoS One, Vol. 10, no. 12, p. e0145497 [1-13] (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0145497 |
| Popis: | Brain blood barrier breakdown as assessed by contrast-enhanced (CE) T1-weighted MR imaging is currently the standard radiological marker of inflammatory activity in multiple sclerosis (MS) patients. Our objective was to evaluate the performance of an alternative model assessing the inflammatory activity of MS lesions by texture analysis of T2-weighted MR images. Twenty-one patients with definite MS were examined on the same 3.0T MR system by T2-weighted, FLAIR, diffusion-weighted and CE-T1 sequences. Lesions and mirrored contralateral areas within the normal appearing white matter (NAWM) were characterized by texture parameters computed from the gray level co-occurrence and run length matrices, and by the apparent diffusion coefficient (ADC). Statistical differences between MS lesions and NAWM were analyzed. ROC analysis and leave-one-out cross-validation were performed to evaluate the performance of individual parameters, and multi-parametric models using linear discriminant analysis (LDA), partial least squares (PLS) and logistic regression (LR) in the identification of CE lesions. ADC and all but one texture parameter were significantly different within white matter lesions compared to within NAWM (p < 0.0167). Using LDA, an 8-texture parameter model identified CE lesions with a sensitivity Se = 70% and a specificity Sp = 76%. Using LR, a 10-texture parameter model performed better with Se = 86% / Sp = 84%. Using PLS, a 6-texture parameter model achieved the highest accuracy with Se = 88% / Sp = 81%. Texture parameter from T2-weighted images can assess brain inflammatory activity with sufficient accuracy to be considered as a potential alternative to enhancement on CE T1-weighted images. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|