| Autor: |
Dhrumil Deveshkumar Patel, Samiksha Bhattacharjee, Avaneesh Kumar Pandey, Chirag Rajkumar Kopp, Abhiram G. Ashwathanarayana, Himani Vinayak Patel, Rohit Barnabas, Sanjay Kumar Bhadada, Manjunath Havalappa Dodamani |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Clinical endocrinology. |
| ISSN: |
1365-2265 |
| Popis: |
Minimally invasive parathyroidectomy (MIP) is the standard of care for primary hyperparathyroidism (PHPT). Four dimensional computed tomography(4DCT) and F-18 Fluorocholine positron emission tomography/computed tomography (FCH PET/CT) localize adenomas accurately to perform MIP.We aimed to conduct a systematic review and metanalysis to evaluate the diagnostic performance of 4DCT and FCH PET/CT scan for quadrant wise localization in PHPT patients and to do head-to-head comparison between these two modalities.After searching through PubMed and EMBASE databases, 46 studies (using histology as a gold standard) of 4DCT and FCH PET/CT were included.Total number of patients included were 1651 and 952 for 4DCT scan (studies n= 26) and FCH PET/CT scan (studies n= 24) respectively. In per patient analysis, FCH PET/CT and 4DCT had pooled sensitivities of 92 % (88-94) and 85% (73-92) respectively and in per lesion analysis, 90% (86- 93) and 79% (71- 84) respectively. In the subgroup with negative conventional imaging/persistent PHPT, FCH PET/CT had comparable sensitivity to 4DCT {84% (74-90) vs 72% (46-88)}. As per patient wise analysis, FCH PET/CT had better detection rates than 4DCT [(92.4 vs 76.85, odds ratio-3.89(1.6-9.36) p=0.0024] in the subpopulation where both FCH PET/CT and 4DCT were reported.Both 4DCT and FCH PET/CT scan performed well in newly diagnosed patients, patients with persistent disease and in those with inconclusive conventional imaging results. FCH PET/CT scan had a higher pooled sensitivity than 4DCT in detecting patients with PHPT in head to head comparison. This article is protected by copyright. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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