Chemistry, biosynthesis and biological activity of terpenoids and meroterpenoids in bacteria and fungi isolated from different marine habitats
| Autor: | Mohsen Gozari, Amir Reza Jassbi, Hesham R. El-Seedi, Maryam Alborz |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aquatic Organisms
Microorganism Biodiversity 01 natural sciences 03 medical and health sciences Marine bacteriophage Flora (microbiology) Drug Discovery Botany Animals Humans Ecosystem Marine fungi 030304 developmental biology Pharmacology Abiotic component Biological Products 0303 health sciences Bacteria Terpenes 010405 organic chemistry Chemistry fungi Organic Chemistry Fungi Marine habitats General Medicine Anthozoa Terpenoid Biosynthetic Pathways Porifera 0104 chemical sciences |
| Zdroj: | European Journal of Medicinal Chemistry. 210:112957 |
| ISSN: | 0223-5234 |
| Popis: | The marine environment with its vast biological diversity encompasses many organisms that produce bioactive natural products. Marine microorganisms are rich sources of compounds from many structural classes with a multitude of biological activities. The biosynthesis of microbial natural products depends on a variety of biotic and abiotic factors in the marine environment, including temperature, nutrients, salinity and interaction with other microorganisms. Terpenoids, as one of the most important groups of natural products in terrestrial microorganisms are important metabolites for marine microorganisms. Here, we have reviewed the chemistry, biosynthesis and pharmacological activities of terpenoids, extracted from marine microbes, and then survey their potential applications in drug development. We also discussed the different habitats in which marine microorganisms are found including sediments, the flora, such as seaweeds, sea grasses, and mangroves as well as the fauna like sponges and corals. Amongst these habitats, marine sediments are the major source for terpenoids producing microorganisms. The marine bacteria produce mostly meroterpenoids, while the fungi are well known for production of isoprenoids. Interestingly, marine-derived microbial terpenoids have some structural characteristics such as halogenation, which are catalyzed by specific enzymes with distinct substrate specificity. These compounds have anticancer, antibacterial, antifungal, antimalarial and anti-inflammatory properties. The information collected here might provide useful clues for developing new medications. |
| Databáze: | OpenAIRE |
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