Low levels of interleukin-1 receptor antagonist coincide with kidney involvement in systemic lupus erythematosus
| Autor: | Jean-Michel Dayer, G Sturfelt, P Roux-Lombard, Frank A. Wollheim |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Kidney Function Tests Nephropathy Proinflammatory cytokine Rheumatology Albumins Internal medicine medicine Humans Lupus Erythematosus Systemic Pharmacology (medical) Longitudinal Studies Prospective Studies Acute-Phase Reaction Interleukin 6 Aged Lupus erythematosus biology Interleukin-6 business.industry C-reactive protein Acute-phase protein Receptors Interleukin-1 Middle Aged medicine.disease Endocrinology Interleukin 1 receptor antagonist Creatinine Immunology biology.protein Female Kidney Diseases business Interleukin-1 Kidney disease |
| Zdroj: | Rheumatology. 36:1283-1289 |
| ISSN: | 1460-2172 |
| Popis: | SUMMARY The objective was to study the relationship between the levels of interleukin-1 receptor antagonist (IL-1Ra) and disease activity and the acute-phase response in SLE patients with and without renal involvement. Twenty SLE patients who had distinct active clinical manifestations (eight glomerulonephritis, four systemic vasculitis without kidney involvement, nine skin rash, 12 arthritis, five serositis, four neuropsychiatric manifestations, three thrombocytopenia, one myositis and one haemolytic anaemia) were studied during a period of 8‐12 months. Serum and plasma samples were taken at intervals of 6 weeks‐ 4 months and tested for IL-1Ra, IL-1b, IL-6, IgG and anti-dsDNA, C1q, C3, C4 and C-reactive protein (CRP). IL-1Ra serum concentrations were increased in most SLE patients with active disease when compared to normal blood donors. However, at the time of flare, significantly higher levels of IL-1Ra were observed in patients with extra- renal disease as compared to other patients (median [range]: 363 [202‐3041] and 4847 [268‐27180] pg/ml for patients with and without renal involvement, respectively). This diAerence was not due to proteinuria. IL-1Ra levels did not correlate with SLEDAI score during flares, but they were elevated during flares in patients with extra-renal manifestations. When disease activity was at its highest, IL-1Ra concentrations correlated with IL-1b (r = 0.76; P |
| Databáze: | OpenAIRE |
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