Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
| Autor: | Ralph N. Martins, Kevin Taddei, Belinda M. Brown, Victor L. Villemagne, S L Macaulay, Veer Bala Gupta, Simon M. Laws, David Ames, Stephanie R. Rainey-Smith, Colin L. Masters, James Lui, Ashley I. Bush, Jeremiah J. Peiffer, Mark Rodrigues, Cassandra Szoeke, Vanessa Ward, Christopher C. Rowe, Tania Taddei, Samantha C. Burnham, Kathryn A. Ellis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male Apolipoprotein E Aging Pathology medicine.medical_specialty medicine.medical_treatment Apolipoprotein E4 Disease Motor Activity Cellular and Molecular Neuroscience chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Insulin Allele Life Style Molecular Biology Alleles Aged Aged 80 and over Amyloid beta-Peptides Cholesterol Functional Neuroimaging Brain Middle Aged Psychiatry and Mental health Endocrinology chemistry Ageing Cohort Female Psychology Biomarkers |
| Popis: | Previous studies suggest physical activity improves cognition and lowers Alzheimer's disease (AD) risk. However, key AD pathogenic factors that are thought to be influenced by physical activity, particularly plasma amyloid-β (Aβ) and Aβ brain load, have yet to be thoroughly investigated. The objective of this study was to determine if plasma Aβ and amyloid brain deposition are associated with physical activity levels, and whether these associations differed between carriers and non-carriers of the apolipoprotein E (APOE) e4 allele. Five-hundred and forty six cognitively intact participants (aged 60-95 years) from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing (AIBL) were included in these analyses. Habitual physical activity levels were measured using the International Physical Activity Questionnaire (IPAQ). Serum insulin, glucose, cholesterol and plasma Aβ levels were measured in fasting blood samples. A subgroup (n=116) underwent (11)C-Pittsburgh compound B (PiB) positron emission tomography (PET) scanning to quantify brain amyloid load. Higher levels of physical activity were associated with higher high density lipoprotein (HDL) (P=0.037), and lower insulin (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|